Embolic strokes of undetermined source: a clinical consensus statement of the ESC Council on Stroke, the EACVI and EHRA LHCH LJMUHealth Liverpool Health Partners #strokes #multimorbidity AFFIRMO Project ARISTOTELES EU Project TARGET academic.oup.com/eurheartj/arti…

These recently published results suggest that PCSK9 inhibitors are effective on the earlier stages of atherosclerosis and warrant further research in larger samples. Take a look!
🔗atherosclerosis-journal.com/article/S0021-…
European Atherosclerosis Society Elsevier Cardiology #CvPrev

What drives human lifespan: genetics or lifestyle?
A new BMJ Evidence-Based Medicine study indicates both, but impact of favorable lifestyle is big
ebm.bmj.com/content/early/…

“Among patients with ASCVD and elevated triglyceride levels, icosapent ethyl significantly reduces the risk of MACE irrespective of baseline CVD risk, though absolute benefits are largest for patients at the highest risk”

Perhaps another important heterogeneous treatment effect 👇🏻👇🏻 (Andrew Foy )

Entresto has benefit in HFrEF but hypotension in HFpEF suggests less benefit in this group

“our data reinforce the benefit/risk ratio favors sacubitril/valsartan in patients with LVEF below normal, but not at higher LVEF”

jacc.org/doi/epdf/10.10…

British Society for Heart Failure #theFword PCCS

🚨 #Tweetorial alert🚨

1) Welcome to a📷 #tweetorial by the @goggledocs team

Our topic for today is Novel agents in #CKD in #T2D

#MedTwitter #NephTwitter

🙏 to A. Menarini Farmaceutica Internazionale SRL for funding this tweetorial.
They have had no input into the content❗️

Research from Family Heart Foundation found only 2% of U.S. patients at high risk of heart disease received a combination lipid-lowering therapy (LLT), and 80% of clinicians never prescribe combination LLTs. bit.ly/3Whf9Ru

Quadruple therapy w/ #ARNI , BB, MRA, #SGLT2i led to decreased risk of CV death & HHF in pts w/ #HFmrEF & #HFpEF . This benefit is largely driven by ARNI, MRA, SGLT2i, which was more pronounced in HFmrEF. bit.ly/3UtIEOD

#JACCHF #GDMT #CHF Stefanos Zafeiropoulos, MD, MS, PhD George Giannakoulas

Newer Pharmacologic Treatments in Adults With Type 2 Diabetes: A Clinical Guideline From the American College of Physicians.

doi.org/10.7326/M23-27…

QRISK4 for cardiovascular disease risk prediction.

Includes 7 new risk factors for men & women:
brain #cancer
lung cancer
#downsyndrome
blood cancer
#COPD
oral cancer
learning disability

& 2 new risk factors in women:
pre-eclampsia
postnatal #depression nature.com/articles/s4159…

QRISK4 is here, more accurate than QRISK3

More accurate than the ASCVD & SCORE2 risk scores in both men & women. Identifies new risk groups & provides superior CVD risk prediction in the UK vs. other international scoring systems for CVD risk

doi.org/10.1038/s41591…

#GLP1RA use and associations with outcomes in heart failure and #T2D . Data from the Swedish Heart Failure and Swedish National Diabetes Registries academic.oup.com/ehjcvp/article…

Great abstract at ACC, garnered a lot of press about post-menopausal women and CAC progression:

Day 1 of #globaltrialssummit starts in 6 hours.... All the major leaders present live. Register at events.hubilo.com/global-trials-… #GTS2024 . Those registered can view all for 12 months.

Clinical Outcomes of Patients with Atrial Fibrillation who Survived from #Bleeding Event: The Results from COOL-AF Thailand Registry LHCH LJMUHealth Liverpool Health Partners #multimorbidity AFFIRMO Project ARISTOTELES EU Project TARGET thieme-connect.de/products/ejour…

🚭 Breaking News

UK MPs have backed by a massive majority a plan to ban anyone born after 2009 from buying cigarettes, effectively ensuring it will become law

bbc.co.uk/news/uk-politi…

Some basic cholesterol biochemistry as it relates to clinical lipidology - note the crucial differences between free & esterified cholesterol. Crucial for its positioning on/within lipoproteins and ability to be exchanged for TG between particles National Lipid Association European Atherosclerosis Society

The Tobacco and Vapes Bill, if passed, will prevent thousands of people being disabled or dying prematurely.

Tobacco addicts people at a young age, taking their choices away and then killing them.

The 4 UK CMOs support creating a smokefree generation.

Do patients with #type2diabetes in RCTs differ from general-practice patients❓

🔹A 🇫🇷 cross-sectional comparative study

👉GP pts compared to RCT
🔸older
⤴️BMI
⤵️smoking
⤵️bp meds
⤵️💔

🔗 bmjopen.bmj.com/content/14/4/e…

Prof Kamlesh Khunti