
Xiangyu Zhang
@xiangyuz0321
Research Assistant Professor
University of Pittsburgh
ID: 1669719700706840576
16-06-2023 14:53:07
43 Tweet
26 Takipçi
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Happy to share our latest review on lysosomal immunometabolic reprogramming in atherosclerosis just published in Nature Reviews Cardiology 🤩 rdcu.be/dUzev #immunometabolism #atherosclerosis Giuseppe Danilo Norata Lab Norata Yvancharvet Laurent Babak Razani, MD, PhD Laboratory


For the #mTor aficionados like us, this paper by Demetriades Lab in Nature Cell Biology parsing the ways mTorc1 senses amino acids at the #lysosome and beyond is a wealth of information. Congratulations on the work for the nutrient-sensing community 👏🏼 nature.com/articles/s4155…

Looks like dietary #protein and amino acids implicated in #metabolic disease & #metabolism again. Excellent work by labs of Weiping Han and Suneng Fu in Cell Metabolism showing high protein intake fuels hepatic lipogenesis and #MASLD #steatohepatitis cell.com/cell-metabolis…

Always exciting when new critical components of #lipophagy (#autophagy of #lipids) are discovered. Kudos to work by Singh lab @autophagie1 in Molecular Cell on identifying VPS4A in hepatic lipophagy to ameliorate #MASLD. Wondering if same in #immune cells? cell.com/molecular-cell…

Cool paper by Lamming Lab in Nature Aging showing that either #protein or #BCAA #isoleucine restriction can improve parameters of #aging, frailty. Very interesting contrast between our data linking #leucine to #CVD and theirs linking #isoleucine to #aging. nature.com/articles/s4358…

Top citations 2024: # 17🏆✨ #Bettina Mittendorfer, Babak Razani, MD, PhD Laboratory (WashU Medicine, University of Pittsburgh School of Medicine) and co-authors describe a leucine mediated threshold effect that regulates #macrophage mTOR signaling and #cardiovascular risk❤️🩹 nature.com/articles/s4225…

Top altmetrics score 2024: #1🏆✨🥇🎇 B Mittendorfer, Babak Razani, MD, PhD Laboratory (University of Pittsburgh, @WUSTL) describe how dietary leucine drives deleterious macrophage #mTORC1 signaling and promote #cardiovascular disease in humans and mice 🐭👥 nature.com/articles/s4225…

Great paper by Lloyd Harvey, MD, PhD & Stephen Chan lab at Vascular Medicine Institute PittDeptofMed in Science Magazine identifying #endothelium NCOA7 as key regulator of #lysosome function, #oxysterol generation, & #PAH #pulmonaryhypertension. Marvelous translational effort. science.org/doi/10.1126/sc…


What we consider poison, #cyanide is generated at low dose endogenously in our cells, occurs in #lysosomes & stimulates #metabolism! That's some wild stuff. Great work by Prof. Szabo lab & colleagues Uni Fribourg in Nature Metabolism. A new "gasotransmitter"! nature.com/articles/s4225…

How does #LowProteinDiet affect #metabolism #energy intake? Great study in humans & mice by Prof. Kiens lab University of Copenhagen Research in Nature Metabolism. #FGF21 is once again endocrine signal extraordinaire of #ProteinRestriction (this time in #AdiposeTissue). nature.com/articles/s4225…

Spilling the skinny on fat cells! ASCI member Babak Razani Babak Razani, MD, PhD Laboratory & team University of Pittsburgh School of Medicine discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/ETdwLJt


Spilling the skinny on fat cells! Babak Razani, MD, PhD Laboratory & team University of Pittsburgh School of Medicine and UPMC discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: jci.org/articles/view/…


Thanks a lot for the great support from my mentor team (Drs. Babak Razani Babak Razani, MD, PhD Laboratory , Zoltan Arany The Arany lab, Michael Jurczak, and Arif Yurdagul Art Yurdagul) as well as Pitt Department of Medicine PittDeptofMed and Vascular Medicine Institute Vascular Medicine Institute.

I also appreciate the help from Dr. Anum Saeed Anum Saeed and all other collaborators/lab members.


A role for protein aggregates in heart failure? This issue’s cover features work from @DiwanlabWustl & team WashU Medicine on protein aggregation in the post–myocardial infarction myocardium: jci.org/articles/view/…


Great showing by Babak Razani, MD, PhD Laboratory at #VascularDiscovery25 in Baltimore the past 3 days. Kudos to the efforts of Kathleen Martin, the entire organizing committee, & American Heart Association for the excellent programming & opportunity to present our work. See you all next year in Bellevue, WA!


Check out our new commentary on #leucine and role in #CVD #atherosclerosis via #mtor #autophagy. Spearheaded by Xiangyu Zhang, Ali Ajam, MD & Babak Razani, MD, PhD Laboratory team we discuss next steps in limiting leucine's damage to the #macrophage & the atherosclerotic plaque. tandfonline.com/doi/10.1080/15…