Xiangyu Zhang (@xiangyuz0321) 's Twitter Profile
Xiangyu Zhang

@xiangyuz0321

Research Assistant Professor
University of Pittsburgh

ID: 1669719700706840576

calendar_today16-06-2023 14:53:07

43 Tweet

26 Takipçi

30 Takip Edilen

Charles Bayly-Jones (@bj_charles) 's Twitter Profile Photo

We are thrilled beyond words to see our LYCHOS (GPR155) publication out today in nature. 🥳 “LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR” nature.com/articles/s4158… 🧵

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

For the #mTor aficionados like us, this paper by Demetriades Lab in Nature Cell Biology parsing the ways mTorc1 senses amino acids at the #lysosome and beyond is a wealth of information. Congratulations on the work for the nutrient-sensing community 👏🏼 nature.com/articles/s4155…

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Looks like dietary #protein and amino acids implicated in #metabolic disease & #metabolism again. Excellent work by labs of Weiping Han and Suneng Fu in Cell Metabolism showing high protein intake fuels hepatic lipogenesis and #MASLD #steatohepatitis cell.com/cell-metabolis…

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Always exciting when new critical components of #lipophagy (#autophagy of #lipids) are discovered. Kudos to work by Singh lab @autophagie1 in Molecular Cell on identifying VPS4A in hepatic lipophagy to ameliorate #MASLD. Wondering if same in #immune cells? cell.com/molecular-cell…

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Cool paper by Lamming Lab in Nature Aging showing that either #protein or #BCAA #isoleucine restriction can improve parameters of #aging, frailty. Very interesting contrast between our data linking #leucine to #CVD and theirs linking #isoleucine to #aging. nature.com/articles/s4358…

Nature Metabolism (@natmetabolism) 's Twitter Profile Photo

Top citations 2024: # 17🏆✨ #Bettina Mittendorfer, Babak Razani, MD, PhD Laboratory (WashU Medicine, University of Pittsburgh School of Medicine) and co-authors describe a leucine mediated threshold effect that regulates #macrophage mTOR signaling and #cardiovascular risk❤️‍🩹 nature.com/articles/s4225…

Nature Metabolism (@natmetabolism) 's Twitter Profile Photo

Top altmetrics score 2024: #1🏆✨🥇🎇 B Mittendorfer, Babak Razani, MD, PhD Laboratory (University of Pittsburgh, @WUSTL) describe how dietary leucine drives deleterious macrophage #mTORC1 signaling and promote #cardiovascular disease in humans and mice 🐭👥 nature.com/articles/s4225…

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Great paper by Lloyd Harvey, MD, PhD & Stephen Chan lab at Vascular Medicine Institute PittDeptofMed in Science Magazine identifying #endothelium NCOA7 as key regulator of #lysosome function, #oxysterol generation, & #PAH #pulmonaryhypertension. Marvelous translational effort. science.org/doi/10.1126/sc…

Nature Aging (@natureaging) 's Twitter Profile Photo

Online now!✨RESEARCH: using multi-omics analysis of patient samples, Zuo et al link disrupted BCAA catabolism to sarcopenia. In mouse models, they demonstrate that enhancing BCAA catabolism protects against sarcopenia nature.com/articles/s4358… rdcu.be/d9SFw

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

What we consider poison, #cyanide is generated at low dose endogenously in our cells, occurs in #lysosomes & stimulates #metabolism! That's some wild stuff. Great work by Prof. Szabo lab & colleagues Uni Fribourg in Nature Metabolism. A new "gasotransmitter"! nature.com/articles/s4225…

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

How does #LowProteinDiet affect #metabolism #energy intake? Great study in humans & mice by Prof. Kiens lab University of Copenhagen Research in Nature Metabolism. #FGF21 is once again endocrine signal extraordinaire of #ProteinRestriction (this time in #AdiposeTissue). nature.com/articles/s4225…

ASCI (@the_asci) 's Twitter Profile Photo

Spilling the skinny on fat cells! ASCI member Babak Razani Babak Razani, MD, PhD Laboratory & team University of Pittsburgh School of Medicine discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/ETdwLJt

Spilling the skinny on fat cells!

ASCI member Babak Razani <a href="/RazaniLab/">Babak Razani, MD, PhD Laboratory</a> &amp; team <a href="/pitt_medicine/">University of Pittsburgh School of Medicine</a> discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/ETdwLJt
Xiangyu Zhang (@xiangyuz0321) 's Twitter Profile Photo

Thanks a lot for the great support from my mentor team (Drs. Babak Razani Babak Razani, MD, PhD Laboratory , Zoltan Arany The Arany lab, Michael Jurczak, and Arif Yurdagul Art Yurdagul) as well as Pitt Department of Medicine PittDeptofMed and Vascular Medicine Institute Vascular Medicine Institute.

Xiangyu Zhang (@xiangyuz0321) 's Twitter Profile Photo

Finally a huge thanks to AHA American Heart Association and PLRC PLRC, whose support will help me for my independence and future research in precision nutrition and immunometabolism.

Journal of Clinical Investigation (@jclinicalinvest) 's Twitter Profile Photo

A role for protein aggregates in heart failure? This issue’s cover features work from @DiwanlabWustl & team WashU Medicine on protein aggregation in the post–myocardial infarction myocardium: jci.org/articles/view/…

A role for protein aggregates in heart failure?

This issue’s cover features work from @DiwanlabWustl &amp; team <a href="/washumedicine/">WashU Medicine</a> on protein aggregation in the post–myocardial infarction myocardium: jci.org/articles/view/…
Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Great showing by Babak Razani, MD, PhD Laboratory at #VascularDiscovery25 in Baltimore the past 3 days. Kudos to the efforts of Kathleen Martin, the entire organizing committee, & American Heart Association for the excellent programming & opportunity to present our work. See you all next year in Bellevue, WA!

Great showing by <a href="/RazaniLab/">Babak Razani, MD, PhD Laboratory</a> at #VascularDiscovery25 in Baltimore the past 3 days. Kudos to the efforts of <a href="/KathyMartinYale/">Kathleen Martin</a>, the entire organizing committee, &amp; <a href="/American_Heart/">American Heart Association</a> for the excellent programming &amp; opportunity to present our work. See you all next year in Bellevue, WA!
Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Check out our new commentary on #leucine and role in #CVD #atherosclerosis via #mtor #autophagy. Spearheaded by Xiangyu Zhang, Ali Ajam, MD & Babak Razani, MD, PhD Laboratory team we discuss next steps in limiting leucine's damage to the #macrophage & the atherosclerotic plaque. tandfonline.com/doi/10.1080/15…