Online now! ✨Kedlian, Wang, Liu et al present the Muscle Aging Cell Atlas Teichlab Veronika Kedlian Kourosh Saeb-Parsy Omer Ali Bayraktar Human Cell Atlas Wellcome Sanger Institute nature.com/articles/s4358… rdcu.be/dEMas

Online now! A new study by Riekelt Houtkooper and coworkers describes lipids that change with age. Bis(monoacylglycerol)phosphate accumulates in older mice and humans, and reduces upon exercise in female research participants.
(rdcu.be/dELBT)
doi.org/10.1038/s43587…

Online now! A new study by Hiroshi Tsugawa and Makoto Arita of the RIKEN IMS metabolomics team and colleagues provides a comprehensive resource of untargeted lipidomics across 13 sample types and 4 ages in mice.
(rdcu.be/dELBu)
doi.org/10.1038/s43587…

Online now! Wu & Tang et al. use single-cell and spatial transcriptomics in reproductively young, middle-aged, and older human ovarian tissue to elucidate ovarian aging. They describe spatiotemporal changes and highlight the regulatory role of FOXP1.
doi.org/10.1038/s43587…

Check our recent Research Highlight on a paper in Nature Biotechnology where researchers used AI trained on aging biology to discover new drugs for fibrosis - incl. a few quotes from study's authors - Insilico Medicine Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs) - rdcu.be/dDO4k nature.com/articles/s4358…

Online now! In a longitudinal population-based cohort, Liu et al., demonstrate that integrating polygenic risk scores and the gut microbiome improved prediction, over traditional risk factors, for heart disease, diabetes, Alzheimer’s, and prostate cancer. doi.org/10.1038/s43587…

Just out Nature Aging👉 Integration of polygenic and gut metagenomic risk prediction for common diseases. nature.com/articles/s4358…

Excellent work by Yang Liu, Dr. Scott C. Ritchie Guillaume Méric and co!

Also see our recent review cell.com/trends/microbi…

REVIEW: Tissue mosaicism, driven by somatically acquired changes, is an emerging hallmark of aging. Kapadia and Goodell combine recent discoveries from the hematopoietic system to integrate this phenomenon into the current framework of stem cell aging. rdcu.be/dA494

Online now! Todorov-Völgyi Katalin , Judit González Gallego et al., provide a #proteomic profile of the #aging brain endothelium identifying a dysregulation of proteins involved in vesicle-mediated transport pathways, most prominently Arf6. rdcu.be/dCnfU

Online now! Salvadó et al., develop and validate a CSF-based staging model for sporadic #Alzheimer , which accurately reflects biomarker and clinical changes, enhancing diagnostic and prognostic assessments of participants for clinical setting and trials. doi.org/10.1038/s43587…

Online now! Adam, Song et al., present a multi-omics analysis of the human midbrain showing age-induced changes in genes associated with glial function, with further alterations of oligodendrocytes in Parkinson’s disease. doi.org/10.1038/s43587…