RESEARCH | Alain De Solis, J. Brüning et al. (@MPI_Metabolism):

The reciprocal interplay between AgRP and POMC neurocircuits governs the precise regulation of food intake and systemic metabolic homeostasis.

nature.com/articles/s4225…

RESEARCH BRIEFING

The authors identify a mechanism that integrates #insulin signaling with distal mitochondrial quality control in #neurons via AMPK/PINK1.

rdcu.be/dErOJ ➡️open link to our Nature Metabolism comment calling for the development and commercialization of tools that reduce the barrier of entry to immunometabolism studies and facilitate the translation of fundamental findings towards clinical applications.

#NatMetabPicks | In nature led by Lai, Beavis & Darcy (@PeterMacCC):

Increased effectiveness of anti #cancer CAR T cell therapy is associated with a stem-like phenotype through increased expression of FOXO1.

nature.com/articles/s4158…

RESEARCH | Alain De Solis, J. Brüning et al. (@MPI_Metabolism):

The reciprocal interplay between AgRP and POMC neurocircuits governs the precise regulation of food intake and systemic metabolic homeostasis.

nature.com/articles/s4225…

Featured in our May issue: Carla Prado and colleagues discuss the pathogenesis, diagnosis and management of sarcopenic #obesity rdcu.be/dE0cx

NEWS & VIEWS | Liangyou Rui (U-M Medical School Research)
The authors use #chemogenetics to simultaneously manipulate two subpopulations of hypothalamic neurons, allowing identification of a pathway that regulates feeding

#NeuroTwitter
🐭🧠🍴

nature.com/articles/s4225…

Online now! NCOR1/2 and glucocorticoid receptor orchestrate hepatic function dlvr.it/T5Ys94

Online now! Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis dlvr.it/T5Ys7w

RESEARCH | V. Sorrentino, J.N. Feige et al. (EPFL, Nestlé Research):

Trigonelline is a human metabolite that can be used for NAD+ synthesis & is shown to improve muscle function in aged worms & mice.

nature.com/articles/s4225…

Online now! NCOR1/2 and glucocorticoid receptor orchestrate hepatic function dlvr.it/T5Ys94

Online now! Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis dlvr.it/T5Ys7w

RESEARCH | V. Sorrentino, J.N. Feige et al. (EPFL, Nestlé Research):

Trigonelline is a human metabolite that can be used for NAD+ synthesis & is shown to improve muscle function in aged worms & mice.

nature.com/articles/s4225…

Online now! Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis dlvr.it/T5PzHj