#ScienceSaturday

What is pyroptosis and how can it activate an antitumor immune response? Pyroptosis is a kind of cell death distinct from apoptosis that is characterized by cell swelling and release of inflammatory mediators. In this study, investigators found that tumor death…

📢 Daiichi Sankyo US and AstraZeneca's ENHERTU has been granted accelerated approval by the U.S. FDA for the treatment of HER2+ cancer, including pancreatic, bile duct, and #colorectalcancer .

Learn how the treatment has shown promising antitumor activity: buff.ly/4aqQEpa

I’ve listened to the video.

To summarise - #AVCT likely has one of the most sought after platform technologies in the #oncology industry.

Tech that enables ‘significant reductions in both severe & mild to moderate toxicities’ & ‘significant antitumor activity’.

#AACR24

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•The antiproliferation effect of #deuterium depleted water (DDW) was confirmed in a cell model.
•DDW inhibits cell proliferation through causing a ROS disbalance in #mitochondria .
•DDW has a potential as an adjuvant in antitumor therapy.

Read the new article by first author Jiuling Yang, published simultaneously at #AACR24 —
PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways.
aacrjournals.org/cancerimmunolr…
UC San Francisco UC San Franciscostemcell UC San FranciscoUrology UC San FranciscoCancer AACR

“ #AVA6000 delivers high concentrations of doxorubicin to the tumor microenvironment (“TME”) relative to plasma, resulting in significant antitumor activity in patients whose tumors have over-expression of Fibroblast Activation Protein (“FAP”).” #AVCT #MBC #AACR24 #AACR2024 #bcsm

Development of a First-in-Class RIPK1 Degrader to Enhance Antitumor Immunity biorxiv.org/content/10.110…

New #JITC article: PD-1 downregulation enhances CAR-T cell antitumor efficiency by preserving a cell memory phenotype and reducing exhaustion bit.ly/49vsOHi #AACR24

📢 our manuscript on the role of gut microbiome in patients with mCRC treated with Cetuximab plus Avelumab doi.org/10.1002/ijc.34…
is one of the most read manuscript published in 2022 in International Journal of Cancer
erika martinelli Giulia Martini Stefania Napolitano Massimo Di Maio

🏆 Exceptional seminar by Fer Aranda based on #immunotherapy #research in peritoneal carcinomatosis and the importance of the #omentum as an immunoregulatory tissue.

#antitumor #ImmunoOncology #CancerResearch
#ResearchToHeal #InvestigarParaCurar

Just published with the #AACR24 presentation in the Novel Antitumor Agents session— Novel WRN Helicase Inhibitors Selectively Target Microsatellite Unstable Cancer Cells.
bit.ly/3VRrhYW
Gabriele Picco Mathew Garnett Garnett Lab Wellcome Sanger Institute AACR

A previously unknown molecular mechanism supports antitumor responses and T-cell survival, according to a recent study from Bin Zhang, MD, PhD, of Lurie Cancer Center Northwestern Feinberg School of Medicine, published in Journal of Clinical Investigation. news.feinberg.northwestern.edu/2024/04/08/nov… Northwestern Medicine #immunotherapy

Our lead therapeutic, misetionamide (GP-2250) is being evaluated in a Phase 1 study to investigate the safety, tolerability, and preliminary antitumor activity in combination with standard of care treatment for patients with #pancreatic cancer.

Our clinical trial sites include:…

Vitamin B6 Competition in the Tumor Microenvironment Hampers Antitumor Functions of NK Cells

Cancer Discovery Oncology Brothers OncoAlert OncoDaily AACR President Philip D. Greenberg Clinical Cancer Research #oncology #Cancer #meded #MedX #AACR24 #AACR2024 Tali Lev Elizabeth McKenna

aacrjournals.org/cancerdiscover…

Monty Montana Can't see the word overvalued. I can read 'significant antitumor activity'.

Vitamin B6 Competition in the Tumor Microenvironment Hampers Antitumor Functions of NK Cells

Cancer Discovery Oncology Brothers OncoAlert OncoDaily AACR President Patricia M. LoRusso Clinical Cancer Research #oncology #Cancer #meded #MedX #AACR24 #AACR2024 Tali Lev Elizabeth McKenna

aacrjournals.org/cancerdiscover…

Novel Mechanism Supports Antitumor Response and T-cell Survival ow.ly/hxar50RcCWK?ut… #Cancer #Medicine #Microbiology #Immunology #Research

Combining the KRAS G12C inhibitor adagrasib with the anti-EGFR antibody cetuximab demonstrated promising anti-tumor effects in patients with KRAS G12C-mutated metastatic colorectal cancer. #cancer #colorectalcancer medboundtimes.com/biotechnology/…

Read the article by the recipients of the Cancer Research Communications Award for Outstanding Journal Article, Jan O. Kemnade, Vlad C. Sandulache, et al.—
Racial Disparities in Immunotherapy Outcomes.
doi.org/10.1158/2767-9…
AACR #AACR24 #OpenAccess

aacrjournals.org/cancerres/arti…

'Interestingly, Orlistat is a novel and rather selective inhibitor of FAS in tumor cells.'