Elizabeth McKenna
@ElizSMcKenna
Executive Editor of Cancer Discovery @CD_AACR, published by @AACR. @BBS_Harvard/@DanaFarber alum. Native New Yorker. Views/likes/RTs are my own. She/her
ID:24753832
https://aacrjournals.org/cancerdiscovery 16-03-2009 19:42:02
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Highlights of FDA Oncology Approvals in 2023: Bispecific T-cell Engagers, Pediatric Indications, and Inclusive Drug Development - via Cancer Discovery. 1st author Joshua M. Donaldson, last author Richard Pazdur Rick Pazdur.
aacrjournals.org/cancerdiscoverā¦
#OCEPublications
Drugging RAS: Moving Beyond KRASG12C ā¦Cancer Discoveryā© aacrjournals.org/cancerdiscoverā¦
Precision Oncology: 2023 in Review ā¦Cancer Discoveryā© aacrjournals.org/cancerdiscoverā¦
From the December issueā
Oncogenic #KRAS Drives Lipo-fibrogenesis to Promote #Angiogenesis and #ColonCancer Progression, by Wen-Hao Hsu, Dr. Ron DePinho et al.
bit.ly/3Tx1eoX
MD Anderson Cancer Center
From the December issueā
#p53 Gain-of-Function Mutation Induces #Metastasis via BRD4-dependent Csf-1 expression, by Gizem Efe, Anil K. Rustgi et al.
bit.ly/3TxHIbJ
@ColumbiaCancer
ICYMI: Electrical signals between skin cells may influence melanoma initiation, according to a new study in Cancer Discovery. Learn more on the #AACRBlog : bit.ly/3RT42vh richard white Dr. Mohita Tagore Memorial Sloan Kettering Cancer Center University of Oxford
New from this issueā
A MITF-eIF3B axis confers therapy resistance in Lethal PCa, by Sandra Santasusagna, Shijia Zhu, Vijayakumar Jawalagatti, Yujin Hoshida, Veronica Rodriguez-Bravo, Josep Domingo-Domenech et al.
bit.ly/4az04PV
Mayo Clinic Urology Mayo Clinic UTSW Simmons Cancer Center @utswnews #ProstateCancer
Readā
Spatial and Temporal Mapping of #BreastCancer Lung #Metastases Identify TREM2 #Macrophages as Regulators of the #Metastatic Boundary, by Ido Yofe, Tamar Shami, N. Cohen, T. Landsberger, Neta Erez- ErezLabš, IdoAmitLab et al.
bit.ly/3RRhZtx
Weizmann Institute Tel Aviv University
In a Cancer Discovery study, Kangsan Kim, Payal Kapur, James Brugarolas, Brekkenlab, Malladi Lab - UTSW, et al. showed that cell competition within a primary tumor shapes #metastatic latency and relapse. x.com/NCICancerBio/sā¦ #NCIHighlights2023
2023 has been a year with major advances in #precisiononcology A must-read in Cancer Discovery
Precision Oncology: 2023 in Review aacrjournals.org/cancerdiscoverā¦
From the December issueā
Formate Supplementation Enhances Anti-Tumor CD8+ #TCell Fitness and Efficacy of PD-1 Blockade, by Jared Rowe, Ilaria Elia, Marcia Haigis, Arlene Sharpe et al.
bit.ly/3NBXqPq
Dana-Farber Harvard Medical School #metabolism #immunotherapy
One-carbon (1C) #metabolism in #immunotherapy for this week's #JEMjc JExpMed
Marcia Haigis @ Arlene Sharpe and colleagues report that 'Formate Supplementation Enhances Antitumor CD8+T-cell Fitness and Efficacy of PD-1 Blockade'šÆCancer Discovery
doi.org/10.1158/2159-8ā¦
Using sequencing approaches in a Cancer Discovery study, Humam Kadara, Linghua Wang, MD, PhD, et al. MD Anderson Cancer Center #NCICSBC revealed the #SingleCell immunogenomic landscape of tumor-infiltrating B and plasma cells in early-stage #LungCancer . x.com/NCIsysbio/statā¦ #NCIHighlights2023 #LCSM
From the December issueā
Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker, by @mTORC3, Connie Wu, David Walt, Kathleen Helen Burns et al.
bit.ly/478IMWX
Mass General Brigham UMLifeSciences Dana-Farber #LiquidBiopsy #TransposableElement
From the December issueā
Structural basis of PML/RARA targeting by #arsenic , by Pierre Bercier, Wang, Zang, Zhou, Hua Naranmandura, De ThƩ, Lallemand-Breitenbach et al.
bit.ly/47VS4ql
CIRB_CdF Inserm HĆ“pital Saint-Louis AP-HP Zhejiang University #APL
Highlights of FDA Oncology Approvals in 2023: Bispecific T-cell Engagers, Pediatric Indications, and Inclusive Drug Development - via Cancer Discovery. 1st author Joshua M. Donaldson, last author Richard Pazdur Rick Pazdur.
aacrjournals.org/cancerdiscoverā¦
#OCEPublications
In Focusā
#PrecisionOncology : 2023 in Review, by Yonina Murciano-Goroff, Sarah Phillips Suehnholz, Alexander Drilon MD, and Debyani Chakravarty, PhD šŗš¦.
bit.ly/41rAwQw
Memorial Sloan Kettering Cancer Center
#PrecisionOncology 2023 in review people! Published in Cancer Discovery & and very soon a table itemizing the key developments to be released on the OncoKBā¢ websiteā¦stay tuned for our last website release for 2023 - it will be a BIG one (HUGE in fact)!