Senotherapeutic repurposing of metformin for age-related diseases and their signaling pathways link.springer.com/article/10.100…

Selective RNA sequestration in biomolecular condensates directs cell fate transitions: biorxiv.org/content/10.110…

🚨Just published in ⁦⁦Nature Aging⁩! 🧬 We discovered that a gut #microbiota-derived metabolite, phenylacetic acid (PAA), accumulates with age and triggers endothelial #senescence, a key driver of cardiovascular #aging. #Saeedi_Lab ➡️ Read more nature.com/articles/s4358…

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —outgrowth of decades of NIH funded research nejm.org/doi/full/10.10… nejm.org/doi/full/10.10… NEJM

Early adherence to the Portfolio Diet (plant-based dietary pattern of cholesterol-lowering foods) may limit lifetime exposure to LDLcholesterol and could delay the age at which cardiovascular events begin, reports a study in #BMCPublicHealth bmcpublichealth.biomedcentral.com/articles/10.11…

Bioinformatics-Guided Experimental Validation Identifies NQO1 as a Senescence-Ferroptosis Hub in Liver Fibrosis mdpi.com/2227-9059/13/5…

In a large-scale proteomic study of biological aging of 11 organs, the biological ages of the brain and immune system emerged as strong predictors of healthspan and longevity, according to a paper in Nature Medicine. go.nature.com/4eFghFq

The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets dlvr.it/TLyB5j

nature.com/articles/s4158… Wow! 1,700 transgenic mice for the most comprehensive enhancer characterization ever. Leo and Axel never cease to amaze!

✅ Read a #blog summary about the #research paper, "Exposome-wide association study of environmental chemical exposures and epigenetic aging in the national health and nutrition examination survey." #Summary ⬇️ aging-us.org/2025/03/how-en… #aging #epigenetics #biology #environment

Proteomic aging signatures across mouse organs and life stages embopress.org/doi/full/10.10…

GrimAge and GrimAge2 Age Acceleration effectively predict mortality risk: a retrospective cohort study tandfonline.com/doi/full/10.10…

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In Cell, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. sciencedirect.com/science/articl…

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures cell.com/cell/abstract/…

Why does RNA undergo glycosylation? Excited to have our new paper out. We in collab w/ Ryan Flynn show N-glycans on glycoRNAs hide self-RNA from endosomal TLRs promoting ‘silent’ clearance of dead cells. nature.com/articles/s4158… UConn Health UConn Research

Have you wondered how incompletely processed and misprocessed RNAs are retained in the nucleus? Check out our new manuscript led by my talented postdoc Lusong Tian! LENG8 mediates RNA nuclear retention and degradation in eukaryotes biorxiv.org/content/10.110…

New Cell Reports paper by Andrew Aguirre Hale Family Center For Pancreatic Cancer Research Integrative genomic identification of therapeutic targets for #PancreaticCancer cell.com/cell-reports/f… VERY GOOD use of public datasets (DepMap, CCLE, TCGA, GTEx) to identify cell intrinsic & cell surface dependencies

RNA-binding proteins mediate the maturation of chromatin topology during differentiation nature.com/articles/s4155…

El origen de la vida en la tierra podría haber ocurrido así, con esta secuencia de tan solo 45 nucleótidos GGC AGG GCA GCG CAG UCG GAC AUU GAU AAC GGA AUC GAG CCC GCC que se puede copiar a sí misma. Impresionante!! science.org/doi/10.1126/sc…

🔬 Review Article | Telomerase Regulation RNA–protein interactions controlling telomerase activity across eukaryotes, with implications for genome stability, aging & disease. 🔗 shorturl.at/70okW #Telomerase #Telomeres #RNAProteinInteractions