An observational study of #FunctionalPrecisionMedicine in #pediatriconcology showed that genomic profiling & ex vivo drug sensitivity testing enabled personalized treatment recommendations within 4 weeks. Arlet Acanda, Ph.D. @Azzamlab Diana Azzam nature.com/articles/s4159…

⭐Research highlight: Designer antibiotics by #generativeAI : Researchers developed an AI model that designs novel, synthesizable #antibiotic compounds — several of which showed potent in vitro activity against priority pathogens. Nature Machine Intelligence
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New data show that ex vivo drug screening of pediatric #cancer samples can identify effective therapies. If validated, this could herald a new approach to #precisiononcology
News & Views from Emmy Dolman, Paul Ekert Peter Mac Cancer Centre Childrens Cancer Institute
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In an updated systematic review and meta-analysis, fixed-dose combination therapy using a polypill with at least one blood-pressure lowering drug and one lipid-lowering drug was found to reduce both incident cardiovascular disease and all-cause mortality
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📢 Looking for your next conference after #AACR24 ? Check out our upcoming Nature Conferences on #cancer #immunotherapy ! Planned w/ Nature Rev Immunol Nature Cancer Nature Immunology
🗓️ Abstract & Early Registration Deadline = THIS Fri, April 12th
🎟️More details here: go.nature.com/CancerImm

By generating synthetic image samples specific to underrepresented groups, diffusion models help medical image classifiers to achieve greater #fairness metrics across a variety of medical disciplines and demographic attributes. Olivia W, Ira Ktena nature.com/articles/s4159…

‘Inverse vaccines’ could treat autoimmune disease — from multiple sclerosis to celiac disease.

Read our latest Clinical Pipeline column, by Carrie Arnold

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At the #AACR24 #LiquidBiopsy minisymposium? Check out this study co-led by Sylvan Baca MD PhD (Hiring!) Toni Choueiri, MD & Matt Freedman showing that a single liquid biopsy assay enables the detection of four epigenomic modifications in a large multi-cancer cohort nature.com/articles/s4159…

At the #AACR24 Immuno-oncology minisymposium? Translational results are being presented from the SWOG Cancer Research Network S1616 trial comparing anti-PD-1 + anti-CTLA-4 #immunotherapy vs anti-CTLA-4 alone in patients with #melanoma . Read the original trial report here nature.com/articles/s4159…

At the #AACR24 #PrecisionOncology #AI session? Check out this recent work led by Sasha Gusev describing a #MachineLearning approach for classifying cancer of unknown primary. nature.com/articles/s4159…

In a large multinational cohort study, maternal, gestational or pregestational #diabetes was associated w/ a small-to-moderate risk of #ADHD in offspring, contrary to previous estimates that showed stronger effect sizes. nature.com/articles/s4159…

Check out this study co-led by #AACR24 #Microbiome session speaker Marcel van den Brink, which shows that baseline gut microbiome composition is associated with response to #CARTcells #immunotherapy nature.com/articles/s4159…

Understanding the provenance and quality of methods is essential for responsible reuse of FAIR data.

Correspondence from Tracey Weissgerber is on LinkedIn and colleagues Charité - Universitätsmedizin Berlin

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A large study points to physical & cognitive function (not age) as predictors of heat-related mortality, therefore #climate adaptation policies should prioritize accessibility.
News & Views from Josiah Kephart & Safiyyah Okoye
Drexel Public Health Josiah Kephart
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Analysis of continuous #GlucoseMonitoring measurements from nondiabetic individuals uncovered inter- & intraindividual variabilities, w/ implications for diagnostic cutoffs for #Diabetes diagnosis & several cardiometabolic clinical measures. Eran Segal
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Off-label use of artificial intelligence models in healthcare.

Comment from Jenna Wiens and colleagues University of Michigan

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At the #AACR24 #Immunotherapy clinical trials session? Check out this trial led by speaker Antoine Italiano, showing improved clinical outcomes in patients with #sarcoma selected for presence of #TertiaryLymphoidStructures after anti-PD-1 #TLS #biomarkers nature.com/articles/s4159…

At the #AACR24 #PancreaticCancer session? Check out this study, which shows that a #DeepLearning algorithm can predict risk of pancreatic cancer from pre-cancer disease trajectories up to 3 years in advance Chris Sander aka cscbio Dana-Farber #AI nature.com/articles/s4159…

At the #AACR24 #glioma session? Check out one of our recent adult IDH mutant low-grade glioma trials, showing the clinical potential of the dual mIDH1/IDH2 inhibitor vorasidenib Memorial Sloan Kettering Cancer Center
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Promoting gender equity in the scientific and health workforce is essential to improve women’s health.

Comment from Cristiani Vieira Machado and colleagues Editora Fiocruz Fiocruz, as part of our series on women's health.

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