Excited to share new results from our 4DN collaboration between the Gilbert, Ma, van Steensel, and Belmont research groups. Joint analysis, led by our trainees, compared chromosome positioning relative to multiple nuclear locales across 4 cell types
doi.org/10.1101/2024.0…

The links are still missing: Revisiting the role of RNA as a guide for chromatin-associated proteins dlvr.it/T5Dxnc

New preview 📰 out in Molecular Cell w/ Mathias L. Nielsen !
'The links are still missing: Revisiting the role of RNA as a guide for chromatin-associated proteins', which discusses the recent studies by Mitch Guttman Chen Davidovich Richard Jenner out this month
authors.elsevier.com/a/1it8J3vVUPRl…

Excited to share our work showing how the Integrator complex terminates RNA polymerase II (Pol II) transcription i.e. removal of Pol II from the DNA template
Published in nature
nature.com/articles/s4158…

Many thanks to my mentor Patrick Cramer Patrick Cramer for unwavering support

Our new paper is out!
cell.com/action/showPdf…

Delivering and expressing a gene in cells is usually a messy (heterogeneous) process. The messiness interferes with research and applications such as gene therapy.
In two new papers, we introduce a toolbox of synthetic miRNA-based control circuits that enable more precise, gene…

(1/14) Excited to share our new work on ZNF143/ZFP143 by Domenic Narducci

ZNF143 has been widely reported to be a general loop factor

Instead we and deWitLab in a companion preprint show that ZNF143 is a TF with no loop function:
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…

Check out our latest story. A groundbreaking study by PhD student Jade Varineau offers insights into the mechanisms underlying splicing stress response. journals.biologists.com/dmm/article/17…
Thanks, MIT Biology for the News Brief biology.mit.edu/news-brief-cal…

What is the role of RNA in PRC2 chromatin association? Pleased to share that Alex Hall Hickman’s work showing that the RNA bridge model is based on an experimental artefact has now been published Cell Reports
cell.com/cell-reports/f…

3/ Another new paper by Richard Jenner with similar conclusions:
cell.com/cell-reports/f…

2/ For more information on our work, see 🧵👇
twitter.com/DavidovichLab/…

1/ Is RNA essential for PRC2 chromatin occupancy? Here we refute evidence that was previously used to support this idea.

Work by Evan Healy and Qi Zhang from the Chen Davidovich, Monash Biomedicine Discovery Institute, EMBL Australia.
cell.com/cell-reports/f…

In the most recent episode we talked with Mitch Guttman from Caltech about his work on characterising the 3D interactions of the genome using Split-Pool Recognition of Interactions by Tag Extension (SPRITE). #epigenetics

Listen here: activemotif.com/podcasts-mitch…

Online Now: Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo dlvr.it/T33rxh