#NewProfile #ALS #MND

Unravelling the role of cell signalling in our molecular mechanistic understanding of amyotrophic lateral sclerosis/motor neuron disease

ppu.mrc.ac.uk/research/princ…

#Auroraborealis this evening !

10 years of Connectomics at Google and a new human cortex publication in Science!

It has been a huge honor to pursue brain mapping advances at Google Research with so many amazing colleagues and collaborators. 🙏

youtube.com/watch?v=VSG3_J…

Trypsin+Lys-C stocks arrived for Team Alessi's MRC PPU Organelle IP Proteomics, Aligning Science Across Parkinson’s...

Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/…

Stunning sunset this evening overlooking Dundee

Overheard someone say “fascinating!” & I agree! Brilliant talk from Miratul Muqit highlighting how mitochondrial & PINK1 research is progressing understanding of #Parkinsons at “ #Parkinsons Research in Scotland” event in celebration of #WorldParkinsonsDay2024

It's out! Neurology: A Queen Square Textbook amzn.eu/d/38X6oko Co-edited with Robin Howard, David Werring and Michael Zandi

We were honoured to celebrate Andrew Larner with his colleagues, friends and family at his Festschrift in Liverpool yesterday. Andrew is our former book review editor and longstanding supporter of ACNR - see acnr.co.uk/acnr-author/aj…

Honoured to have spoken at Andrew Larner #Festschrift Liverpool Medical Institution in Liverpool with Roger Keynes, Parashkev Nachev, Saif Huda celebrating a career rich in neurological research and scholarship and mentoring countless trainees ACNR - A journal of neurology & rehabilitation The Barker / Williams-Gray Lab Alasdair Coles Alexander Leff

Immensely proud and excited by the launch of Outrun Therapeutics! With our fantastic team, technology and investors, I look forward to the new protein-stabilising medicines Outrun will develop by modulating the ubiquitin system. #ubiquitin #E3ligases

linkedin.com/posts/outrun-t…

More than excited to share Uche's comprehensive review on BMP, a unique lysosomal lipid. We survey the past work of giants in the field, identify open questions to inspire people joining this emerging space and describe the therapeutic potential of targeting the BMP pathway.

Multiple sclerosis can be diagnosed solely with dissemination in space: Yes - Ahmed T Toosy, Frederik Barkhof, 2024 journals.sagepub.com/doi/10.1177/13…

Identification and structural characterization of small molecule inhibitors of PINK1, from the Jean-Francois Trempe group
nature.com/articles/s4159…

Characterisation of RT-QuIC negative cases from the UK National CJD Research and Surveillance programme. There aren’t many negatives but collectively they are younger and have atypical clinical features and prion strain types. link.springer.com/article/10.100…

Cool paper from our neighbors Johannes Walter and Ernst Schmid in Harvard Med BCMP describes a new classifier for improving alphafold-based interaction screening. biorxiv.org/content/10.110…

Love this picture of us staggering up Downing Street yesterday. So proud of what moversandshakerspod along with Parkinson's UK Cure Parkinson's and Spotlight YOPD have done to highlight the need for better Parkinson’s care with our #ParkyCharter

Molecular machines rule! Frank Adolf & Jiale Du in Brenda Schulman lab Max Planck Institute of Biochemistry (MPIB) , John Hanna (BWH/Harvard), & Ellen Goodall Wade Harper Harvard Med Cell Bio visualize chaperone-mediated stepwise assembly of the 20S proteasome by cryo-EM Aligning Science Across Parkinson’s nature.com/articles/s4159…

Very sorry to hear Peter Higgs has died. I was fortunate enough to meet him several times, and beyond being a famous physicist - I think to his embarrassment at times - he was always charming and modest. And of course his name will be remembered as long as we do physics in the…

People living with #Parkinson ’s disease use their brains more to stay motivated, a study from @UodMedicine reveals.

Patients can create a pathway in their brain to prevent apathy, a common symptom of the illness.

buff.ly/43Oxebf