“Elucidating mechanisms underlying motor coordination rescue in a mouse model of ARSACS” research report from Dr. Watt and Dr. McKinney (McGill University). This project was funded by the Foundation in 2022-2023.
arsacs.com/wp-content/upl…

First in-human trial of an mRNA therapy to treat an inborn error of metabolism (propionic acidemia). Not just one, but two gene products were delivered to hepatocytes (PCCA and PCCB encoding α and β subunits of the deficient protein). Amazing!
Koeberl et al. Nature

Wow, this is pretty brazen.
This article (right) from He'nan University of Science and Technology copied **all data** from an article by Université du Québec authors (left), released 2 months earlier.
Found by imagetwin
#ImageForensics
pubpeer.com/publications/C…

Identification and structural characterization of small molecule inhibitors of PINK1, from the Jean-Francois Trempe group
nature.com/articles/s4159…

Cool paper from our neighbors Johannes Walter and Ernst Schmid in Harvard Med BCMP describes a new classifier for improving alphafold-based interaction screening. biorxiv.org/content/10.110…

A new computational approach to de novo protein design enables the creation of drug-binding proteins with accurate design and prediction binding energy and specificity, researchers report in Science.

📄: scim.ag/6Ad

Potential starting points for new #psychedelics ?

Halogenated tryptophans!

nature.com/articles/s4146…

A reminder that MTSViewer (developed by PhD student Andrew Bayne) is active and was used by over 400 users across the world in the past 3 months. Your one-stop place to look at the structure, mutations, and processing of your favorite mito proteins: mtsviewer.neurohub.ca

PINK1 regulated mitophagy is evident in skeletal muscles
tandfonline.com/doi/full/10.10…

figure: PINK1 ko decreases basal mitophagy in skeletal muscles, especially in oxidative fibres while POLGD257A mildly increases it.

important work by the Ganley Lab for anyone interested in #ageing

Nobel Prize winner acknowledges errors in three more papers
The papers, published in the Journal of Neuroscience and Cell, were led by neuroscientist Thomas Südhof.
Shaena Montanari The Transmitter

thetransmitter.org/publishing/nob…

Johannes Herrmann Johannes Herrmann and colleagues show that ER-mitochondria #contact sites are essential for the import of hydrophobic #mitochondrial precursor proteins to the inner mitochondrial #membrane via the ER-SURF pathway. uni_kl Anne Spang

embopress.org/doi/full/10.10…

We just published our investigation on PINK1 inhibitors; PRT062607, a SYK inhibitor, also inhibits PINK1 (IC50 1 uM). The inhibitor is not selective for PINK1, but paves the way to the development of PINK1 selective chemical probes: nature.com/articles/s4159…

Did you miss'The 'Mighty' HSQC', the 2nd #Bruker NMR Training Webinar of 2024?
Watch the recording here: goto.bruker.com/3TvBk3e

The HSQC experiment is an incredibly useful and versatile #NMR experiment: Martine Monette discusses its evolution.

#NMR Training #Bruker NMRTraining

We determined the structure of anti-FLAG-M2 in complex with the FLAG peptide, with a surprising twist in the result. Great work by Matti Pronker Wouter biorxiv.org/content/10.110…

Le sous-financement de la recherche scientifique est tel qu'une génération entière de chercheurs et chercheuse risque d'être perdue. La journaliste Fannie Bussière-McNicoll explique pourquoi il est urgent que le Canada renverse cette tendance.

ici.radio-canada.ca/ohdio/balados/…

The team of Yang Zhang (Chengdu) have created a database of membrane contact sites - 44 of them! - with more than 600 low-throughput MCS proteins, as well as many more documented in high-throughput experiments - either by proximity ligation or mass spec.

nature.com/articles/s4159…

New non-profit, Conscience, targeting under-researched diseases: mcgillnews.mcgill.ca/new-non-profit… McGill Faculty of Law | Faculté de droit McGill University aled edwards

Interested in NMR? Take a look at Gary’s expert advice article.

Our article on PINK1 forming a complex with TOM and TIM23 is out today. Congrats Mohamed and Andrew! Great collaboration with the Fon lab. pnas.org/doi/10.1073/pn…

Our new publication in the Journal of Parkinson's Disease provides a comprehensive and compelling summary of all the evidence that supports the growing recognition that #Parkinson disease is largely an environmentally caused condition.

Open access paper: content.iospress.com/articles/journ…