Dream come true! So grateful to UK Research and Innovation, MRC PPU and everyone who has helped along the way. This will be transformational for my group! As I finish my Sir Henry Wellcome Fellowship this year, I would also like to thank Wellcome for investing in me, incl. my PhD.🙏

All set! Today we welcomed ten YINs and some of their lab members for our EMBO YIP NeuroYIP Sectoral meeting. Exciting science ahead!

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions: Neuron cell.com/neuron/fulltex…

Delighted to join the SAB of Montara Therapeutics, Inc. which seeks to develop new drugs for a host of #neurological disorders using revolutionary technology from Kevan Shokat. Stellar team led by Co-Founder Nicholas Hertz. Looking forward to exciting drug discovery ahead!

Super excited to announce that I have joined MRC Laboratory of Medical Sciences (MRC LMS) to start my group here lms.mrc.ac.uk/research-group…, continuing studies on AMPK & exploring its roles in immunity & ageing. Recruiting research technician to join my lab! #hiring #AMPK #metabolism #immunity nature.com/naturecareers/…

We’ve worked out how the molecular machines that create acidic compartments can recruit autophagy (self-eating) machinery when they can’t maintain a pH gradient. We are really pleased with this discovery, out in Molecular Cell cell.com/molecular-cell…. 1/16

💡 Special Issue highlight 💡 Allosteric regulation of kinase activity in living cells: elifesciences.org/articles/90574… Want to see more like this? Explore the Special Issue: elifesciences.org/collections/eb…

New Preprint: We investigated HRI, a potential new target in cancer and Parkinson's disease. Using HDX-MS we looked at how heme binding inhibits the kinase, including (the surprising 😲) tyrosine autophosphorylation activity of this S/T kinase... 1/2 doi.org/10.1101/2024.0…

4 more days to apply 👇🏻 if you’re an interdisciplinary scientist keen to develop your career, this is for you! Come join us 🤓

Out Now! Updated story on #HRI kinase as a negative regulator of #PINK1 mitophagy. We now show that the small molecule ISR inhibitor #ISRIB boosts PINK1 activation. Collaboration with Ganley Lab Rousseau Lab MRC PPU & Glenn Masson Click here for paper shorturl.at/G0IzL

🚨 New paper alert from @martenssascha!🚨 We explore how transmembrane cargo receptors initiate selective autophagy. Through biochemical reconstitutions, we discover a new autophagosome biogenesis pathway with implications for therapeutic interventions. biorxiv.org/content/10.110…

Pleased to have contributed to this exciting new story on #Parkin activation from Atul Kumar Lab #Parkinson #mitophagy mechanisms Click to read paper here: elifesciences.org/articles/96699

We are taking part in Doors Open Days on Sun 29 September! Visit the School of Life Sciences & WeeCAIR Medicinal Garden WCAIR Univ of Dundee from 11am - 3pm. We’ll be running bookable tours of the inside of our complex at 12 noon and 2pm Info & tour booking: buff.ly/3SDq9Wx

Researchers leading groundbreaking cancer and Parkinson’s research have been given almost £30 million to bolster their vital work over the next five years. 👏 We are enormously grateful to Medical Research Council – UKRI for their generous support for MRC PPU. More: buff.ly/3XbPTuA

As a medical student I had the privilege of attending one case in person led by late great MF Beal then Professor at MGH Neurology. Electric experience! As a SHO at the Hammersmith Hopsital @imperialmed - learned loads at daily Morning Reports inspired by NEJM case records

Our latest preprint! Some beautiful cell biology in this one. "Presynapses are mitophagy pit stops that prevent axon degeneration" biorxiv.org/cgi/content/sh… Discoveries into the cell biology of of mitophagy in axons, a disease mechanism, and a potential therapeutic avenue. 1/2

Can you pronounce Protein Phosphorylation and Ubiquitylation? linkedin.com/posts/medical-… UoD Life Sciences Medical Research Council

Here is our updated preprint on STING, CASM and GABARAP-dependent activation of LRRK2 at lysosomes: doi.org/10.1101/2023.1… This reflects incredible thought and perseverance from Amanda Bentley-DeSousa!!! She discovered the LRRK2-GABARAP interaction and now shows the basis for it.