Rigorous work provides #FirstEvidence for gold standard of pluripotency in primates cell.com/cell/fulltext/… However. Not all naïve primate ESCs are the same from the perspective of the embryo and even the ones that yield chimeras, do so at a low freq. Much to think @ #MustRead

Can we talk about how inconvenient it has gotten to get a visa for Chinese students? It’s been 3 weeks since mine was “refused”. Is there any reason me, in my 2nd yr Stanford PhD, must wait for up to 180 days to be considered safe to be let in the US?

Gene expression involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. We developed ChIP-DIP – a method for simultaneous, genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. biorxiv.org/content/10.110…

'What we're endeavoring to do is by no means guaranteed to succeed — and it wouldn't be as exciting if it was.' Jay Shendure discusses Seattle Hub for Synthetic Biology w/TechCrunch Chan Zuckerberg Initiative Allen Institute UW Medicine techcrunch.com/2023/12/07/sea…

However, amidst the myriad of predicted RBPs, it's unclear which ones affect exon inclusion directly. Our latest research Nature Biotechnology evaluates hundreds of RNA binding proteins for their role in enhancing exon inclusion. link.springer.com/article/10.103…

Structural variants (SV) impact more nucleotides per human genome than other forms of genetic variation. To better understand SV impact, we developed a method to 'shuffle' mammalian genomes and characterize them with single-cell resolution in a pool. biorxiv.org/content/10.110…

Fluorogenic CRISPR for genomic DNA imaging nature.com/articles/s4146…

We (with wei yang and Jay Shendure) are thrilled to announce our new paper on the "human RA-gastruloid" model, showcasing morphologies and transcriptomes akin to E9.5 (mouse) or CS10-11 embryos (biorxiv.org/content/10.110…). (1/n)

Interested in segmentation? In this Review we integrate in vivo and in vitro studies to detail mechanisms of somite formation in the early embryo. Give it a read, we'll guide you through the fascinating process of somitogenesis! Nature Reviews Molecular Cell Biology nature.com/articles/s4158…

We are delighted to share our new preprint entitled “A male-essential microRNA is key for avian sex chromosome dosage compensation” biorxiv.org/content/10.110…

Want to hear about the latest updates/new techniques in single cell and spatial genomics? Check out the full agenda for our Single Cell Genomics Day on Friday, 3/29. All talks will be live-streamed (no registration required) at satijalab.org/scgd

Excited to have lineage motifs out in the world. Hoping the concept and methods can be useful in various developmental systems as more lineage data become available. Congratulations to Martin Tran and Amjad Askary on the work, and thanks to Adara Koivula and Inna-Marie for

Jessica Osterhout PhD These materials I have assembled are in part an attempt to demystify some of the hidden curriculum of academia: docs.google.com/document/d/1jB…

Our work on studying chromatin context-dependent regulation of prime editing is officially out on @Cell. cell.com/cell/fulltext/…

Cool work! Congratulations!

Great to see, first hand, this initiative develop The Jackson Laboratory with @eliseinsing. ‘A watershed moment’ for a shadow disease: first state-mandated endometriosis biorepository launches in Connecticut | Science | AAAS science.org/content/articl…

Excited to share our human RA-gastruloid model in Nature Cell Biology! Early retinoic acid supplementation, followed by later Matrigel addition, robustly induces human embryonic morphologies and diverse cell lineages, including somitic, renal, cardiac, and neural cell types in

I am so thrilled to share our work of human RA gastruloid finally out on Nature Cell Biology. It has been a wonderful journey to work with a fantastic stem cell scientist Nobu Hamazaki and many talented collaborators in Jay Shendure lab. Excited to contribute to the field of stembryo!

Very happy to share our latest w/ Devin Schweppe and Nobu Hamazaki labs, where we map the temporal dynamics and proteomic landscape of mammalian gastruloids. Sneek Peak 🧵below #stembryo #gastruloid #proteomics biorxiv.org/content/10.110…

Incredibly proud to share that I recently joined UCSF Bioengineering & Therapeutic Sciences UC San Francisco as an Assistant Professor! This means that the Calderon Lab is now open! Or, more accurately, in the process of opening as I am still unboxing equipment and unraveling giant posters (a last @JSHendure lab gift) 🥳