As my lab develops Seurat, I wanted to share some thoughts on the important Seurat and scanpy package selection preprint from Joseph Rich/Lior Pachter 🧵

Happy to see this paper out! Congrats to the lab, especially MD/PhD student par excellence Zach Walsh

Very happy to share some of my PhD work, published yesterday in Nature Biotechnology. Especially thankful for truly exceptional mentorship from my PI, bizarMD, who encouraged me to leverage powerful gene editing tools to ask some exciting questions bridging immunology and genetics

The 2024 CSH Asia meeting "Computational Biology of the Genome" is only 3 months away. An exciting lineup of speakers, short talks to be selected from abstracts, and fellowship/travel award for select trainees! Come & join us in the beautiful guarden city Suzhou! 🔥🔥🔥

Led by incredible MD/PhD student Karan Luthria

One small step for man, one giant leap for organ-on-chip!🚀 Read more here: bit.ly/3LVWi7U

Our annual department retreat Columbia Systems Biology! Exciting science and beautiful venue in PA.

We’re excited to officially launch CZ Biohub New York! With Columbia University, Rockefeller University, and Yale University, work is already underway at #CZBiohubNY, building on what’s known about immune cells & leveraging insights to teach our own cells how to fight and win against dangerous diseases.

As astronauts venture deeper into space, radiation risks soar! To gauge the threat, Gordana Vunjak-Novakovic researchers on Earth are studying the effects of simulated space radiation on human tissue models. Read how their findings could one day protect cosmic explorers: go.nih.gov/GA8G7Za

Happening this Thursday -- the Engineering in Medicine Symposium at Columbia University University! From AI & imaging to genomics, biomechanics, and tissue engineering, discover how engineering is transforming medicine from bench to bedside. Check out the incredible lineup of speakers

Congratulations to Lindsay Caprio somnath tagore, many people in my group, and outstanding collaborators Denis Kresimir Bestak Fei Chen Lab Caris Life Sciences and many others on this paper, profiling non-small cell lung cancer brain metastases nature.com/articles/s4159…

Multi-omic single-cell and spatial analyses of lung cancer brain metastases from multiple cohorts identify high levels of chromosomal instability and a neural-like profile in metastases compared to primary tumors nature.com/articles/s4159…

‼️🧠 New research from bizarMD in Nature Medicine leverages single-cell & genomic profiling with machine learning to uncover how non-small cell lung cancer rewires itself to spread to the brain. Read more! cancer.columbia.edu/news/neural-hi…

We look forward to hearing from Banjamin Izar, MD, PhD on Apr 1: The Sting of Metastatic Reactivation and Progression cancer.columbia.edu/profile/benjam… Herbert Irving Comprehensive Cancer Center Hosted by Emily Bernstein, PhD, Emily Bernstein Lab Icahn School of Medicine at Mount Sinai

New Nature Medicine paper: “Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases.” Caris WES/WTS data validated high chromosomal instability in brain metastases vs. primary tumors. Learn more: ow.ly/mnZK50VynlR

Happy to contribute in the manuscript “The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin”, published in Molecular Cell. Congrats Elena Elena Grossi. Thank you Emily Bernstein Lab and @bizarmd. cell.com/molecular-cell…

My postdoc work in the Emily Bernstein Lab Icahn School of Medicine at Mount Sinai is online Molecular Cell!🔥 🔎We explored the unique functions of the PBAF complex and its relationship with TFs and unveiled a PBAF/REST-controlled neuronal-like signature with potential implications in melanoma brain mets🧬

"...our research shows that the PBAF complex keeps certain genes shut off in #Melanoma,” said Emily Bernstein, PhD, Emily Bernstein Lab mountsinai.org/about/newsroom… Elena Grossi Icahn School of Medicine at Mount Sinai

Congratulations to Columbia's Dr. Andrea Califano and the #CZBiohubNY team on the launch of GREmLN (Gene Regulatory Embedding-based Large Neural model)! czbiohub.org/news/czi-ai-mo…