Lior Pachter(@lpachter) 's Twitter Profileg
Lior Pachter

@lpachter

Bren Professor of Computational Biology @caltech. Blog at https://t.co/FFQzhEJpji. #methodsmatter

ID:31936449

linkhttp://pachterlab.github.io/ calendar_today16-04-2009 16:12:04

24,6K Tweets

41,7K Followers

2,0K Following

Lior Pachter(@lpachter) 's Twitter Profile Photo

Sad to learn today that Sigurður Helgason, who was a math professor Massachusetts Institute of Technology (MIT) when I studied there, passed away on December 3rd. mbl.is/frettir/innlen…

account_circle
Kevin Buzzard(@XenaProject) 's Twitter Profile Photo

The Gowers-Green-Manners-Tao proof of Marton's polynomial Freiman-Ruzsa conjecture terrytao.wordpress.com/2023/11/13/on-… has now been completely formalised by a team led by Tao. It took three weeks! The project was run on the Lean Zulip; here's Tao's announcement leanprover.zulipchat.com/#narrow/stream… .

account_circle
Lior Pachter(@lpachter) 's Twitter Profile Photo

This reply by chatGPT is wrong. Then again, I asked chatGPT if this was written by chatGPT and it correctly replied in the affirmative. 🤔

account_circle
Ben Golub 🇺🇦(@ben_golub) 's Twitter Profile Photo

Interestingly, the oscillatory structure of eigenvectors criticized in this paper might be important and 'real.'

In 'Targeting Interventions in Networks,' (Econometrica 2021) we show that they determine the optimal shape of some economic interventions.

twitter.com/ben_golub/stat…

account_circle
Lior Pachter(@lpachter) 's Twitter Profile Photo

The Borsuk problem is special, and I got immersed in it when I read the Kahn-Kalai counterexample to the conjecture in the mid 1990s (it used Frankl-Wilson!) Progress on the problem is seemingly slow (decades / result) but on the timescale of math, this is the blink of an eye.

account_circle
Lior Pachter(@lpachter) 's Twitter Profile Photo

🎶 UMAP Fails, UMAP Fails,
But publish anyway,
Oh, what a tale of woe and bale,
When data sets are saved. Hey!
UMAP Fails, UMAP Fails,
Clusters hide and flee,
In this maze of endless scales,
Confusion reigns, for the referee! 🎶

account_circle
Laura Luebbert(@NeuroLuebbert) 's Twitter Profile Photo

Colab notebook to reproduce the BRCA2 experiment: github.com/pachterlab/gge…

gget repo: github.com/pachterlab/gget

account_circle
Laura Luebbert(@NeuroLuebbert) 's Twitter Profile Photo

Can you spot the difference between these two BRCA2 protein sequences?

They are 3,418 amino acids in length and only differ in a single amino acid.

Yet, women expressing the mutant BRCA2 protein have a high likelihood of developing breast cancer. Why is that?

Can you spot the difference between these two BRCA2 protein sequences? They are 3,418 amino acids in length and only differ in a single amino acid. Yet, women expressing the mutant BRCA2 protein have a high likelihood of developing breast cancer. Why is that?
account_circle
Tal Korem (@tkorem.bsky.social)(@tkorem) 's Twitter Profile Photo

Breaking my exTwitter hiatus to announce our broad open-rank search in areas of quantitative / computational biology at the Program for Mathematical Genomics,Columbia University. Feel free to reach out with questions and please share.

jobs.sciencecareers.org/job/653640/fac…

account_circle
Kresten Lindorff-Larsen(@LindorffLarsen) 's Twitter Profile Photo

Lior Pachter Rita Strack John Novembre Matthew Stephens Yes, we even had a thread on this about 5 years ago (x.com/LindorffLarsen…) including alsohow Berk Hess identified this issue in 2000 in PCA of MD simulations in:
Similarities between principal components of protein dynamics and random diffusion

@lpachter @rita_strack @jnovembre @mstephens999 Yes, we even had a thread on this about 5 years ago (x.com/LindorffLarsen…) including alsohow Berk Hess identified this issue in 2000 in PCA of MD simulations in: Similarities between principal components of protein dynamics and random diffusion
account_circle
Daniel Litt(@littmath) 's Twitter Profile Photo

In fact I have a talk I sometimes give to general audiences which opens with this issue: static1.squarespace.com/static/57bf2a6…

account_circle
Lior Pachter(@lpachter) 's Twitter Profile Photo

I discovered the song Bein’ Green yesterday thanks to Audra McDonald who delivered a moving rendition at LA Opera.

“And I think it’s what I want to be”…

youtu.be/reANE3oM_-I

account_circle
Lior Pachter(@lpachter) 's Twitter Profile Photo

When I was a grad student I took “Kletiman’s combinatorics seminar” Massachusetts Institute of Technology (MIT) where on day one he’d present a paper that a student would pick at random. Kleitman would try to prove the result after only reading the abstract. If successful he’d say “maybe this was too easy to publish.”

account_circle