🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation: Cell Metabolism cell.com/cell-metabolis…

Cell membranes sustain phospholipid imbalance via cholesterol asymmetry: Cell cell.com/cell/fulltext/…

NEW content online! Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities bit.ly/4iQunoF

We report that Cyclin D1 is an important direct target of HIF2 that drives the proliferation of ccRCC. Our findings further support the notion of combining HIF2 and CDK4/6 inhibitors to enhance antitumor activities. Congrats to Nitin Shirole and the team!

The 2025 Breakthrough Prize in Life Sciences was awarded to: Drucker, Habener, Holst, Knudsen, and Mojsov for GLP-1/ozempic, Hauser and Ascherio for treating multiple sclerosis, and David Liu for CRISPR base editing. Terrific choices!

📢 New preprint alert! 🚨 We show that diet quality, not just quantity, is a key player in driving pancreatic cancer progression. 🔑 What you eat may matter for cancer risk—much more than we previously thought. #PancreaticCancer #CancerBiology #DietAndCancer

Amino acids in cancer: Understanding metabolic plasticity and divergence for better therapeutic approaches dlvr.it/TK1KCg

Congratulations Dr. Cenik Bercin K Cenik for the development of a revolutionary method that will change the way we will do our chromatin biochemistry/genetics studies. nature.com/articles/s4156… Northwestern BMG and SQE Northwestern Feinberg School of Medicine nature Nature Medicine Nature Reviews Cancer Molecular Cell

Can we talk? The cryptic communications of hepatic stellate cells in lipid metabolism dlvr.it/TK2Yn6

1/ Why do late-stage cancer patients lose motivation & sink into apathy? 🔥Our new Science paper shows cancer activates a cytokine-sensing brain circuit to lower motivation.Great work by Aelita Zhu Sarah Starosta Marco Pignatelli Tobias Janowitz &team!🧵 🔗 doi.org/10.1126/scienc…

"Why do I no longer enjoy my favorite food and activities?" - an important question from our patients with cancer and cachexia! Cancer is a disease of the whole body, including the brain. Kepecs Lab Marco Pignatelli Míriam Ferrer Gonzalez Cancer Grand Challenges Cold Spring Harbor Laboratory science.org/doi/10.1126/sc…

Congrats Claudia Tonelli and the Tuveson lab! FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development aacrjournals.org/cancerres/arti…

Online now - Lipids: emerging actors in mitochondrial protein import dlvr.it/TKCBTq

Review Molecular Cell Brandon Chen, PhD @Lyssiotislab @Yatrikshahlab Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis cell.com/molecular-cell…

Excited to share new report from collaborative work from Delgoffe Lab and Patrick Jonker from our team on a novel metabolic suppressor of T cell function in tumors! rdcu.be/eiyIa 1/

Interested in the mysteries surrounding metastasis evolution? This perspective in Nature Reviews Cancer is my best attempt at proposing a framework that could help advance our thinking about the topic. Well. At least it helped advance my own thinking. 😅 nature.com/articles/s4156…

Check out our new paper in Nature Biotechnology sharing our latest kinase activity reporters! Led by former postdoc Michelle Frei, these reporters are based on HaloTag rather than an FP, for far-red imaging and superresolution! nature.com/articles/s4158…

Now online in Cancer Discovery: Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis - Benjamin Kahn, Ben Stanger, and colleagues doi.org/10.1158/2159-8… Penn Medicine Penn Medicine - Abramson Cancer Center

Why do tumors tend to metastasize to lymph nodes? Super interesting insights into this question, published online in Cancer Discovery today. One of those papers that grabs you at the title.

Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (Lyssiotis Lab Arul Chinnaiyan), has just been published in nature! U-M Rogel Cancer Center Rogel and Blondy Center for Pancreatic Cancer University of Michigan Medical School Michigan Pathology Michigan Research UMich CMB