This recent review from Perurena, Situ & Cichowski (@HarvardMed & Brigham and Women's Hospital) outlines combinatorial strategies for treating #RAS -driven cancers.

The 4 main conceptual approaches are shown.

Check out the paper for more details 👇
go.nature.com/49OijPu

NEW content online! Investigating immune cells across time in vivo dlvr.it/T5rxLq

Worried about the application of AI in oncology? Check out our (Nature Reviews Cancer) latest Comment by Stephen Gilbert and Jakob Nikolas Kather advocating for novel regulations on GMAI approaches to ensure patient safety and adequate physician support.

Published in nature, Judith Agudo, Omer Yilmaz and teams, explore the mechanisms of immune evasion in early colorectal cancers and adenomas. They identify SOX17 as crucial for #immuneescape through suppression of IFN-y signaling.

More details here👇
go.nature.com/4ay3ba5

Combinatorial strategies to target RAS-driven cancers

📌We can now target what was once thought untargeted, the RAS. However, we still have a long way to go.
A great review on combination strategies👇

OncoAlert
nature.com/articles/s4156…

Great to hear from Anna Dart from Nature Reviews Cancer on publishing and a focus on #sexdifferences and #cancer - including our recent perspective on sex bias in immune responses with Zihai Li, MD, PhD Juyeun Lee Tong Xiao

Chronic stress contributes to increased rates of metastasis and poor prognosis in #patientswithcancer . Now, Mikala Egeblad and group establish that stress induces #neutrophilextracellulartrap (NET) formation to promote metastasis.

Check out our highlight 👇
go.nature.com/3VTyl7z

Tumour-associated lymphatic growth & remodeling were once viewed as passive means for lymphatic spread. In this #Review , Amanda Lund Lab provide a working framework for the role of the lymphatic system in tumour progression & response to immunotherapy.

go.nature.com/442H4GG

Dr Judith Campisi passed away earlier this year. Pierre-Yves Desprez and Pankaj kapahi honor her personal and scientific contributions in this Obituary.

go.nature.com/441JKUE

NEW content online! Combinatorial strategies to target RAS-driven cancers dlvr.it/T5bYVg

In this #ToolsoftheTrade article, Kaile Wang describes the development and use of #Arcwell , a high-throughput #singlecell #DNAsequencing method tailored to analyze archival FFPE materials.

go.nature.com/43Xkn6G

While it is incredibly rare that patients with paediatric cancer develop unrelated, second cancers without known germline predisposing variants, Nuria Lopez-Bigas, Jaume Mora et al. investigated the possible routes to these second malignancies.

Highlighted here 👇
go.nature.com/440u7wX

NEW content online! Guardrails for the use of generalist AI in cancer care dlvr.it/T5ZR2n

As part of our Series on #SexDifferences in cancer, Justin Lathia, PhD 🧠🕺🏽, Zihai Li, MD, PhD &Co wrote a Perspective article that outlines the biological factors contributing to #sexbias in immuno-oncology. Check it out: go.nature.com/3TQ0fP6

Metastasis research is hindered by the availability of metastatic tumour samples from patients. In this Comment, Christine Desmedt & Lisa Carey, MD, ScM, FASCO highlight the opportunities + challenges of post-mortem tissue donation programs to overcome these hurdles.

go.nature.com/3xtcwRZ

As part of our Series on #SexDifferences in cancer, Berna Özdemir Universität Bern summarises the evidence for greater drug toxicity observed in female patients & emphasizes the need for increased awareness of sex differences at all stages of drug development. go.nature.com/4an1Q62

NEW content online! Programming immune escape dlvr.it/T5QCJr

NEW content online! NET-working under stress dlvr.it/T5QCJN

NEW content online! Lymphatic vessels in the age of cancer immunotherapy dlvr.it/T5MqCc

As part of our Series on #SexDifferences in cancer, we highlight the complex issues that concurrence of cancer & pregnancy can pose. In their Comment, Letícia Varella & @annpartridgemd present approaches to solve them. go.nature.com/3PZRUXZ