Check out our latest review online today Nature Reviews Cancer - we synthesize the lymphatic vessel literature in the context of the rapidly evolving field of cancer immunotherapy Triantafyllia #TennyM Perlmutter Cancer Center at NYU Langone Health NYU Grossman School of Medicine

rdcu.be/dEswn

Spp1+ Macs are always bad news… in the heart (science.org/doi/10.1126/sc…)… and in colon cancer… (and many other examples)

Spatially Segregated Macrophage Populations Predict Distinct Outcomes In Colon Cancer | Cancer Discovery aacrjournals.org/cancerdiscover…

This is pretty striking. Take one single cell experiment, split it into random 'batches', correct the batches, and look at change in nearest neighbor cell rank. Big changes (not good)!

Very excited to share our latest preprint on somatic mutations in the normal stomach. We found many surprises, incl. hypermutant glands, recurrent somatic trisomies and a unique landscape of driver mutations. Thread below! biorxiv.org/content/10.110…

Great to see this fascinating study published - all tumor evolution enthusiasts should definitely read!

Excited to announce our 'deep profiling' of 18 human cancers! Incorporating all available cancer expression data into DNNs was my first idea 14 years ago when joining UW. Honored to work with brilliant minds, Wei Qiu Allen School and Kamila Naxerova Harvard Medical School!
biorxiv.org/content/10.110…

What happens if you study 50K cancer transcriptomes in a lot of analytic depth, and through the lens of a really good deep learning model?

I loved working on this fascinating project with Su-In Lee! We dug into the data like maniacs😱

Read more 👇

biorxiv.org/content/10.110…

There's still a week left to register for the Mutations in Time and Space conference.

Join us 23-25 April in beautiful Edinburgh, UK.
mutationmeeting.com

We've a stellar lineup of speakers and even a traditional Scottish cèilidh after the gala dinner!

Wow, what a fabulous session this was - I learned so much! Many thanks to Benjamin D. Greenbaum, Stephen Martis and The Mark Foundation for Cancer Research!!

We are hiring to fill Research Tech positions. Ideal candidates are graduating seniors looking to gain 2+ years of immersive research experience related to the development and application of genome editing tech. Details can be found on our lab website: kleinstiverlab.org/open-positions

Very proud to have my lab contribute to the development of the tools to generate and precisely quantify epistatic effects in complex genotypes in mouse models of lung cancer: biorxiv.org/content/10.110… and biorxiv.org/content/10.110… Monte Winslow's Lab

Before we had a polio vaccine.

Thanks for highlighting our work Cancer Discovery ! #ResearchWatch

Want to hear about why physicists are working on leading edge quantitative questions in cancer evolution? Stephen Martis and I organized a session at #apsmarch on Quantitative Insights into Cancer Evolution: meetings.aps.org/Meeting/MAR24/…

APS-DBIO American Physical Society The Mark Foundation for Cancer Research

“We particularly centre our discussion on potential mechanisms of mechanical memory formation and retention via mechanotransduction and persistent epigenetic changes.” - very interesting nature.com/articles/s4156…

We are hiring Research Technicians! We are looking for a self-motivated, inquisitive, ambitious, and enthusiastic team player who thrives in a fast-paced environment. Ideal for candidates seeking research experience for grad school applications. Please RT! mskcc.org/research/ski/l…

Very excited to release Sequoia, our pipeline for phylogenetic tree reconstruction from mutations in normal cells. A detailed description is now published in Nature Protocols! nature.com/articles/s4159…

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Today I'm happy to share our work on tumor karyotype selection, explored experimentally in Stephen Elledge's lab!

nature.com/articles/s4158…