Out now! Our newest paper on how blood stem cells retain their regenerative potential and vitality with age.

Paper link: nature.com/articles/s4155…

More info and video abstract: tinyurl.com/4u7hud78

#StemCells #Aging #Hematopoiesis

Summary below:

Can anti-aging antibodies revive the immune system? In Nature News & Views we previewed the latest breakthrough from Irv Weissman's team in @Nature that used immunotherapy to deplete aging stem cells. Yasar Arfat T Kasu nature.com/articles/d4158…

Fantastic to have our paper 'Deciphering cell states and genealogies of human hematopoiesis' published today in nature as an Accelerated Article Preview! We describe ReDeeM! Awesome work led by Chen Weng in a wonderful collaboration with Jonathan Weissman's Lab!

nature.com/articles/s4158…

Tonight: Come learn about how we can target the proteostasis network in AML with new UCSD Sanford Stem Cell Institute faculty Dr. Kent Lam. #ASH23

Join us this morning to learn about hematopoietic stem cell fate and fitness from 6 amazing speakers! #ASH23

Please join us today from 3-4pm for Dr. Fuchs seminar!

I am thrilled and honored to share our lab's most recent work from the highly talented Diego López @___Dlopez___ as a preprint , available now on BioRxiv:
biorxiv.org/content/10.110…

bit.ly/3YIHmzT Registration is open for our Sanford Stem Cell Institute Symposium 10/19-10/20. Join in-person or virtually at no cost #stemcells #UCSD #UCSanDiego #stemcells yposium

Thank you Stephanie Xie, HopeCancerLab and everyone at Princess Margaret Cancer Centre Research for an amazing visit filled with spectacular science. Always great to be back home in Toronto. Big thanks to Aaron Schimmer for the invitation!

PLEASE RETWEET!!!
UC San Diego Bioengineering and UCSD Engineering is hiring for multiple Assistant Professor positions in #Bioengineering . Come join our diverse group of amazing faculty, students, and staff! #DiversityInSTEM #AcademicChatter #AcademicTwitter

apol-recruit.ucsd.edu/JPF03742

UC San Diego FIRST Program is hosting an information session webinar for potential applicants on Sept. 13! Register for the webinar at go.ucsd.edu/3YCyknX. Registration required. #hiring #TenureTrack #AssistantProfessor #academia #sciencejobs #postdoc #STEMM #AcademicTwitter

The next cycle of the applications is now open! UCSD is hiring new diverse Assistant Professors through the #NIHFIRST Program! First review date: Oct. 1st. Learn more at first.ucsd.edu. Apply now at apol-recruit.ucsd.edu/JPF03666

Today, we get to see IN PRINT what happens when the beauty of megakaryocytes and the brilliance of Maria N. Barrachina combine
I could not be more excited to share our publication, revealing that both MK maturation and platelet production rely on membrane PUFAs. 🧵👇
rdcu.be/dg3aH

So excited to share our new publication in Nature Immunology! We leveraged new bioinformatics pipelines and a synthetic biology approach to identify a novel GPCR-Gs-PKA immune checkpoint promoting T cell exhaustion and cancer immunology failure. nature.com/articles/s4159… Eytan Ruppin, MD, PhD

Excited to share the latest work from our lab investigating the response of fetal hematopoiesis to congenital infection, out today in The EMBO Journal . Truly exceptional work by students Diego Lopez Kelly Otsuka and April Apostol, in collaboration with Kirk Jensen Kirk Jensen

Delighted to have our paper, led by Jorge Diego Martin-Rufino, on conducting massively parallel base editing screens in primary human hematopoietic cells out in Cell today. Can help improve therapeutic approaches for #leukemia and #sicklecell disease:

cell.com/cell/fulltext/…

Online debut of the new new 🔥 from the MK to Plt Group with Joseph Italiano

Our new story in RPTH- Fearlessly led by JuliaTilburg and Andy Stone using single cell spatial to show that where MKs are in the bone marrow matters!! 🦴

sciencedirect.com/science/articl…

Ever wonder what happens when DNA transcription clashes with mRNA translation? Sujata Jana @FredHutch did and discovered a new tumor suppressive process called transcriptional-translational conflict caused by loss of #ARID1A ! Out today Cancer Cell cell.com/cancer-cell/fu… 1/n

Somatic mutations accumulate in “normal” non-cancerous tissues (blood, skin, liver). But why are mutant clones selected? Do they merely proliferate more, selfishly? Or can clones adapt to disease? Could they protect tissues? We shed light on this: authors.elsevier.com/a/1gua9L7PXmc1- 1/10