Exciting to see what our discoveries have led to so far!! Lights a 🔥 under us, as well as many other physicians and scientists!

Published today, our reasons for optimism that success rates in drug discovery can be improved by picking the right targets using human genetics: nature.com/articles/s4158…

I break the key findings down panel by panel in this thread: x.com/cureffi/status…

Our new ms “Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain” is now at nature . rdcu.be/dEmgT! We report on human forebrain dynamic assembly during development…1/n

The future of heme-onc is very very bright!!! Congratulations!!! 👏👏👏

Outstanding Kober Lecture from David Ginsburg from University of Michigan and HHMI NEWS at the ASCI, #AAP , APSA JointMeeting!!! Amazing to hear about his career during this insightful talk!

Grateful to meet this amazing group, including 2023 Lasker Foundation Award Winner and fellow The Harvard/MIT MD-PhD Program alumni David Huang, at the ASCI meeting who helped contribute to advances that saved my retina! 🙏🙏🙏

Incredibly proud of Richard Voit who is a recipient of a 2024 ASCI Emerging-Generation Award!!! Congratulations, Richard!!

As Mackay and Anholt emphasise, epistasis is typically not observed in analyses of common variant effects in humans *for methodological reasons*, not because it doesn't exist

Excited to share with you our manuscript describing the endogenous protein La as a mediator of prime editing and the development of our PE7 editor, which can improve prime editing. For more, please check out nature.com/articles/s4158…

Sallie Permar MD PhD and I just published this today in STAT. #pediatricians are the foundation of our health care system and have an impact over the life course of our nation's health care. We make a difference!! AMSPDC American Board of Pediatrics (ABP) APPD Mark Del Monte, JD
statnews.com/2024/04/02/too…

Wow!!

The haematology community recently lost an exceptional researcher, mentor, role model and friend. I was honoured to prepare this tribute with ⁦David Kent⁩ for ⁦ISEH⁩ Exp Hematol. 🙏 to those who contributed, ♥️ to the Eaves family exphem.org/article/S0301-…

I am excited to share our preprint: “A torpor-like state in mice (TLS) slows blood epigenetic aging and prolongs healthspan”. Congratulations to Lorna Jayne and big thanks to our collaborators Prof Steve Horvath, Vijay Sankaran, Vadim Gladyshev and others.
biorxiv.org/content/10.110…

Can anti-aging antibodies revive the immune system? In Nature News & Views we previewed the latest breakthrough from Irv Weissman's team in @Nature that used immunotherapy to deplete aging stem cells. Yasar Arfat T Kasu nature.com/articles/d4158…

Why do Latino children have the highest risk for childhood leukemia in the US? We identify one cause for this in a paper out in Cell Genomics today, led by Adam de Smith, Lara Wahlster, Soyoung Elizabeth Jeon, Fulong Yu, Charleston Chiang, & colleagues:
cell.com/cell-genomics/…

📢 Happy to announce our new review on stem cell #aging ! We integrate traditional concepts/hallmarks of aging with emerging data on somatic evolution and stem cell competition. Nature Aging

nature.com/articles/s4358…

Why can RNA only be linear or circular? It can be branched! We made multi-tailed mRNA, and we had fun! Here is our story led by brilliant graduate student Hongyu Chen: rdcu.be/dB7ck and his cartoon illustration👇MIT Chemistry Broad Institute

Delivering and expressing a gene in cells is usually a messy (heterogeneous) process. The messiness interferes with research and applications such as gene therapy.
In two new papers, we introduce a toolbox of synthetic miRNA-based control circuits that enable more precise, gene

Incredibly delighted that Jorge Diego Martin-Rufino and Soumyaa Mazumder from our lab both matched for their pediatrics residencies at the Boston Combined Residency Program ( #BCRP ) at Boston Children's and Boston Medical Center!!! Congratulations!!! The future of pediatrics (+ heme/onc) is very bright!!

Was inspiring to interview one of the people I admire tremendously and a leader in developing curative therapies for #sicklecell disease, Courtney Fitzhugh, for the ASCI Perspectives Series! Please check it out:
vimeo.com/923567201