Alcohol-associated liver cancer pubmed.ncbi.nlm.nih.gov/38607725/

Latest news: will be moving back to WI at end of this year after 30+ years away from home. Transitioning our program to Morgridge Institute and UW-Madison CRB. Excited for our lab members to visit & plan things out. Madison has phenomenal regeneration and zebrafish communities &...

Nice work Dan Siegwart, co-leader of the Chemistry & Cancer Program in the Simmons Cancer Center, leading this initiative with Pfizer that will impact the patients we serve in North Texas!! Daniel Siegwart
utsouthwestern.edu/newsroom/artic…

Excited to share our latest paper on Molecular Cell! A joint effort with Martina Panatta which showed different mechanisms of BAZ2A depending on the nature of RNA binding. Check it out! RaffaellaSantoroLab

sciencedirect.com/science/articl…

Using highly accurate & sensitive sequencing technology, our #SomaticGenomics platform reveals a new universe of somatic genome variation. Learn how our technology works to identify these novel links between genes & disease: brnw.ch/21wIGGM

the eclipse in dallas revealing the CRI Logo! it’s a sign!! ⁦Children’s Research Institute at UT Southwestern⁩

We are looking for a scientist to lead the CRI transgenic core. This is an opportunity to run a core AND to create a cutting-edge research program on in vivo gene editing. We've made > 200 new GEMMs since 2018, now we want to innovate! Please retweet cri.utsw.edu/facilities/mou…

Sam C. Wang is the epitome of a surgeon-scientist. Recently awarded second NIH R01 grant studying gastric cancer. Rarefied air!! Superstar researcher but better person. UTSW Surgery UT Southwestern Medical Center UTSW Simmons Cancer Center

The first clinical trial using a mRNA-nanoparticle to deliver a protein replacement, which gets into liver cells and restores mitochondrial function. For a life-threatening, ultra-rare disease that has no treatment.
New nature, with results in 16 patients
nature.com/articles/s4158…

New treatment will transform people's lymph nodes into ‘mini livers’

The first person has received the therapy, made by @LyGenesis, as part of a trial for people with liver failure and can’t get a transplant.

For nature, w/ Valérie Gouon-Evans Michael Hufford
nature.com/articles/d4158…

Very excited to share our review on genetic variation across and within individuals led by Zhi Yu Tim Coorens! nature.com/articles/s4157… Nature Reviews Genetics

1/BILIARY ATRESIA remains the main indication for liver transplantation in children. Best outcomes are associated with early diagnosis and intervention.

#livertwitter #pediatricsurgery #biliaryatresia #FIINDGreenInStool

Excited to have lineage motifs out in the world. Hoping the concept and methods can be useful in various developmental systems as more lineage data become available. Congratulations to Martin Tran and Amjad Askary on the work, and thanks to Adara Koivula and Inna-Marie for…

Human cancer is a disease of somatic mutations. As we age, tissues accumulate errors in DNA, but what causes mutations in young healthy cells? Read our new paper “Childhood cancer mutagenesis caused by transposase-derived PGBD5” science.org/doi/10.1126/sc… 1/n

Excited to share our paper 'Inter-organ steroid hormone signaling promotes myoblast fusion via direct transcriptional regulation of a single key effector gene'. Congratulations to Zhi-Rong Ruan and all co-authors for a beautiful and comprehensive study! authors.elsevier.com/a/1insd3QW8S6D…

One of the more important extrapolations from the data here is that cfDNA assays (mutations or methylation) alone are quite suboptimal for sensitivity in early stage #PancreaticCancer . Criticism of CA19-9 is justified, but by themselves cfDNA assays perform worse in early stage.

Apply now for the 2025 Mark Foundation Emerging Leader Award! Grants are awarded to early-career investigators in US and Canada for projects addressing unmet needs in cancer research. Deadline to apply is April 29. For more information, please visit bit.ly/3Iw678s

Paper alert from our great Ana Belén Plata Gómez, PhD ! mTOR as the hepatocyte GPS: Postnatal control of mTORC1 activity in the liver is critical for the establishment of spatial (portal-central) metabolic differences.

nature.com/articles/s4146…

Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury: Cell Stem Cell cell.com/cell-stem-cell… Lab's first work for liver regeneration: Cyp2e1-DreER mouse model + single-cell spatiotemporal computational modeling for novel discovery!

MKK4 was originally identified as a regeneration target using in vivo shRNA screens in the liver. This effort paves the road for drugs that improve liver regeneration in the clinic. Kudos to Lars Zender and colleagues!