Incredibly delighted that Jorge Diego Martin-Rufino and Soumyaa Mazumder from our lab both matched for their pediatrics residencies at the Boston Combined Residency Program ( #BCRP ) at Boston Children's and Boston Medical Center!!! Congratulations!!! The future of pediatrics (+ heme/onc) is very bright!!

Fantastic to have our paper 'Deciphering cell states and genealogies of human hematopoiesis' published today in nature as an Accelerated Article Preview! We describe ReDeeM! Awesome work led by Chen Weng in a wonderful collaboration with Jonathan Weissman's Lab!

nature.com/articles/s4158…

Remarkable to see that our discoveries over 15 years ago would enable such tremendous advances for sickle cell disease and thalassemia!!! Incredible to think that the final sentence of our 2008 paper would be prophetic (science.org/doi/10.1126/sc…)...

statnews.com/2023/11/16/u-k…

All of the base editor plasmids and the CROP-seq vector described in this paper are available at Addgene:

addgene.org/browse/article…

Please check them out!

Our Cell Reports Methods Spotlight written by Alina Vaitsiankova and Tanay Thakar on the beautiful work of Vijay Sankaran, Jorge Diego Martin-Rufino and colleagues using base editing screens to map variant effects in human hematopoiesis
cell.com/cell-reports-m…

#132: Inferring gene regulation from stochastic transcriptional variation across single cells at steady state Anika Gupta Jorge Diego Martin-Rufino Shari (Grossman) Kennedy Cleary Eric Lander

Theory for Qs on the tech. horizon, crucial for ensuring proper data analysis!

pnas.org/doi/10.1073/pn…

This link should work for all authors.elsevier.com/a/1hEo%7E5Eb0R…

Congrats again to Vijay Sankaran and team on this tour de force study showcasing diverse base editor screens in blood cells @Cell:
cell.com/cell/pdf/S0092….
It was fun writing this spotlight piece out now Trends in Immunology sciencedirect.com/science/articl…

🚀 Excited to announce Dynamo v1.3 for advanced modeling of scRNA-seq and vector field learning & prediction! A big step towards our v2.0.0 goal by the end of 23'. Get it now on PyPi (shorturl.at/gvzB4)! #RNAVelocity . See fully refactored preprocessing module, more below

This could be transformative in determining the significance of genetic variants uncovered in the work up of #bonemarrowfailure patients.

Editing blood stem cells, base by base, reveals changes that could affect blood cell biology and contribute to blood diseases. Kudos Vijay Sankaran Jorge Diego Martin-Rufino & team 👏 learn more ⬇️ Cell Broad Institute ms.spr.ly/6016gVzFy

Delighted to have our paper, led by Jorge Diego Martin-Rufino, on conducting massively parallel base editing screens in primary human hematopoietic cells out in Cell today. Can help improve therapeutic approaches for #leukemia and #sicklecell disease:

cell.com/cell/fulltext/…

Now online! Massively parallel base editing to map variant effects in human hematopoiesis dlvr.it/SnQmm9