Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile
Babak Razani, MD, PhD Laboratory

@razanilab

Razani lab @ Center for Immunometabolism cim.pitt.edu, U. of Pittsburgh studies macrophages, autophagy-lysosomes, nutrient signaling in metabolic disease

ID: 1222213330900832256

linkhttp://www.razani.org calendar_today28-01-2020 17:43:54

198 Tweet

1,1K Followers

698 Following

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Congratulations to our team member, Dr. Xiangyu Zhang Xiangyu Zhang, Assistant Prof. PittDeptofMed Vascular Medicine Institute & Core Director of Center for #Immunometabolism: Got DOUBLE awards this week 😱 (American Heart Association Career Development Award & PLRC P&F Grant). Sky's the limit 💪

Congratulations to our team member, Dr. Xiangyu Zhang <a href="/XiangyuZ0321/">Xiangyu Zhang</a>, Assistant Prof. <a href="/PittDeptofMed/">PittDeptofMed</a> <a href="/PittVMI/">Vascular Medicine Institute</a> &amp; Core Director of Center for #Immunometabolism: Got DOUBLE awards this week 😱 (<a href="/American_Heart/">American Heart Association</a> Career Development Award &amp; <a href="/PLRC_PittLiver/">PLRC</a> P&amp;F Grant). Sky's the limit 💪
Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Herculean effort by @Polash_23 diwanlab_wustl & team in Journal of Clinical Investigation showing role of CRYAB & #proteinaggregation in #heartfailure, ischemic #cardiomyopathy. This is beyond role in genetic CM. Congrats also on cool cover! Happy to have collaborated with you over the years 🤝

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Interesting new concepts by Dillin Lab in Cell on #autophagy #aggrephagy in "quiescent" cells actually inducing #lysosome damage that is curbed by #TFEB & UPR response. Novel way of looking at this & excited to see its role in #aging & disease. cell.com/cell/abstract/…

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Lots to like about work of Greg_Steinberg lab in Nature Metabolism on #adrenaline stimulating #adipocyte #lipolysis (via ATGL) to activate #macrophage #GDF15 action on brain centers for #anxiety. Adipose-immune-brain axis also relevant to metabolic disease. nature.com/articles/s4225…

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Timely review of #precisionnutrition as strategy in #CVD #metabolism disease therapy in Nature Medicine by Marta Guasch, PhD Jordi Merino & colleagues. Note that uncovering mechanisms linking nutrients to cellular signaling true power of precision #nutrition. nature.com/articles/s4159…

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Look who got his 1st corresponding author paper in Journal of Investigative Dermatology on #tcell MyD88/A20 & psoriatic #arthritis? Congrats Dr. Bahram Razani Bahram Razani, Dermatologist-Scientist extraordinaire UCSF School of Medicine. Best wishes as you setup the "other" RazaniLab💪😁 sciencedirect.com/science/articl…

Look who got his 1st corresponding author paper in <a href="/theJIDJournal/">Journal of Investigative Dermatology</a> on #tcell MyD88/A20 &amp; psoriatic #arthritis? Congrats Dr. Bahram Razani <a href="/BahramRazani/">Bahram Razani</a>, Dermatologist-Scientist extraordinaire <a href="/UCSFMedicine/">UCSF School of Medicine</a>. Best wishes as you setup the "other" RazaniLab💪😁
sciencedirect.com/science/articl…
Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Bonanza of cool papers recently on curious BMP #lipids only found in #lysosomes, discovery of degrading enzyme PLA2G15, and role in physiology & disease by labs of Judith Simcox PhD in Cell Metabolism and Monther Abu-Remaileh in nature. nature.com/articles/s4158… cell.com/cell-metabolis…

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Check out our new commentary on #leucine and role in #CVD #atherosclerosis via #mtor #autophagy. Spearheaded by Xiangyu Zhang, Ali Ajam, MD & Babak Razani, MD, PhD Laboratory team we discuss next steps in limiting leucine's damage to the #macrophage & the atherosclerotic plaque. tandfonline.com/doi/10.1080/15…

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Hunting for the next key metabolite besides #TMAO driving #atherosclerosis #CVD? Need to read excellent work by David Sancho in nature implicating gut #microbiota derived "ImP" with possible links to our favorite #macrophage #mtor signaling in the plaque. nature.com/articles/s4158…

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Blocking #CD47 has emerged as promising therapy in #CVD. Check out work in Circulation by Zhen Guo of Ali Javaheri lab identifying CD47 in #cardiomyopathy #heartfailure induced by doxorubicin & targeting it as novel therapy. Great partnering with you on this. ahajournals.org/doi/10.1161/CI…

Blocking #CD47 has emerged as promising therapy in #CVD. Check out work in <a href="/CircAHA/">Circulation</a> by Zhen Guo of <a href="/Alicardsdoc/">Ali Javaheri</a> lab identifying CD47 in #cardiomyopathy #heartfailure induced by doxorubicin &amp; targeting it as novel therapy. Great partnering with you on this. ahajournals.org/doi/10.1161/CI…
Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

LIPA locus #SNP (#Lysosome Acid Lipase gene) long known as #CVD risk. Cool work by Fang Li of Hanrui Zhang lab in European Society of Cardiology Journals uses high-tech functional #genomics to uncover mechanism backed by mouse model. Thanks for including us in the journey. academic.oup.com/eurheartj/adva…

Babak Razani, MD, PhD Laboratory (@razanilab) 's Twitter Profile Photo

Super discovery by Irfan Lodhi in nature today. BCFA, which are #fattyacids derived from #BCAA like #leucine, are metabolized in #peroxisomes as new form of #brownfat #thermogenesis (heat production). Thanks for including us in this multi-year effort 💪 nature.com/articles/s4158…