A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments Nature Cell Biology nature.com/articles/s4155…

Just out Nature Immunology
A single infusion of engineered T cells put asthma in long term remission in the mouse model
nature.com/articles/s4159…

Press release: the addition of pembro to neoadjuvant chemo improves OS in stage II-III TNBC.

Tremendous news for one of the greatest unmet needs in breast oncology.

Next step: tailoring strategies to preserve the benefit while minimizing IO-toxicities.

merck.com/news/merck-ann…

Pancreatic cancer has historically been difficult to diagnose early, but there is hope on the horizon. Scientists have developed a blood test that can accurately detect early-stage #PancreaticCancer , according to results from a large study. go.nih.gov/JDvWoix #NCRM24

Intracranial CAR-T cell delivery in glioblastoma patients

cell.com/trends/cancer/…

Don´t miss this Review summarizing the different antibody-based approaches for targeting cancer cells including #CheckpointInhibitors , bispecific antibodies and #AntibodyDrugConjugates , as well as strategies that improve efficacy and reduce toxicities.

go.nature.com/3wWetGE

#ASCO24
Real-world data from the largest dataset to date on the efficacy of T-DXd in mBC.

Of course, it will be presented by the master of HER-Low and ADCs, Paolo Tarantino💥

📌You should definitely take a look at this study. There is very valuable data on the HR situation and

We always learn a lot from the publications of “unsuccessful” trials

MEDI7247 was an ADC targeting ASCT2, with a PBD (DAR2) conjugated to a site-specific Cys inserted after position S239 (C239i)

Half-life of both ADC and total mAb was very short (<24h)!

link.springer.com/article/10.100…

UNIVERSAL DISEASED HEMATOPOIETIC SYSTEM REPLACEMENT: Antibody–drug conjugate targeting CD45 & transplantation of CD45-targeting refractory HSCs enables the selective eradication of leukemic cells with preserved hematopoiesis nature Simon Garaudé Romina Matter Marone
nature.com/articles/s4158…

NEW content online! Developmental origins shape the paediatric cancer genome dlvr.it/T6L4X9

🗓️ NCI Center for Cancer Research is hosting Past, Present and Future of Cellular Immunotherapy. Make sure to attend it on September 26.

National Cancer Institute, NIH, NIHClinicalCntr, NIH Intramural, Surgery Branch

linkedin.com/events/past-pr…

#CCRNews : A new #AI tool can look at images of a brain tumor and quickly predict its subtype and methylation state. 🧠

Eytan Ruppin, MD, PhD, Kenneth Aldape, MD, National Cancer Institute

ccr.cancer.gov/news/article/n…

Comprehensive peripheral blood immunoprofiling reveals five immunotypes with immunotherapy response characteristics in patients with cancer dlvr.it/T6xVdw

Viewpoint discusses cancer antigen expression and antibody drug conjugates. ja.ma/4bGnK4p

Learning from *canine* cancer models? Imagine what we might learn from sequencing the tumors our canine companions, who have high genetic, microbiome, and immune system similarity to us. Potential to increase survival times of pets and humans alike! cancerletter.com/trials-and-tri…

Check out the latest articles Nature Cancer 'Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling' doi.org/10.1038/s43018…

SCI leader Crystal Mackall & others identify #macrophages as major regulators of T-cell persistence & illustrate the fundamental challenge of combining T-cell-directed therapeutics with those designed to activate macrophages. go.nature.com/4apN0L6 #CARTcells #CD47
Mackall Lab

FDA granted accelerated approval to tarlatamab-dlle for extensive stage small cell lung cancer with disease progression on or after platinum-based chemotherapy.

fda.gov/drugs/resource…

#OCENewsBurst

A deep learning model is used to classify central nervous system tumors based on their DNA methylation profile directly from histopathology and showed high accuracy in a large set of external validation cohorts, potentially informing downstream treatment.
nature.com/articles/s4159…

Excited to share joint effort shorturl.at/gjCOR with Eytan Ruppin, MD, PhD group in Nature Medicine, where we use deep learning to predict DNA methylation patterns from H&E images. Working to develop further to assist in diagnostics.
#neuropath #pathology #PathTwitter