Are ICIs safe in pts with solid organ transplant? Multicentre retrospective study Jordi Remon ESMO Open:

- 31pts (98% kidney, 36% NSCLC)
- irAEs➡️ICI stop 12.9%
- rejection rate 25.8% (mono 28% combo 33% p NS)

A privilege to review this paper OncoAlert
sciencedirect.com/science/articl…

Excited to share our new paper in Cell on spatial organization in glioblastoma authors.elsevier.com/c/1izT9L7PXqQI9. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal five-layer organization of cellular states and a role of hypoxia as tissue organizer. 1/

'Clonal expansion in normal tissues'
onlinelibrary.wiley.com/doi/10.1111/ca…

Immune checkpoint blockers in pts with solid organ transplant and solid tumors. Potential treatm for some pts but limited activity for pts with SOT and 🫁cancer.1/3 have organ rejection within 2mo after treatment initiation.Thanks all authors! OncoAlert
authors.elsevier.com/sd/article/S20…

New #OpenAccess study suggest that neoadjuvant platinum-based ICI-chemo. for those with early-stage #NSCLC is associated with improvements in 2-year EFS and pCR 🫁

See the full study in JAMA Network Open by Giuseppe Banna, Mona Hassan, Alfredo Addeo MD & colleagues ⬇️

jamanetwork.com/journals/jaman…

Cancer cell metabolism and antitumour immunity dlvr.it/T5sjWm

Phosphoproteomic Analysis Identified Mutual Phosphorylation of FAK and Src as a Mechanism of Osimertinib Resistance in #EGFR Mutant 🫁 Lung Cancer
🔸️defactinib/
🔸️saracatinib/
🔸️osimertinib
🔻
doi.org/10.1016/j.jtoc…

🔈JTO: Pool de 442 pts com CPCNP PD-L1 ⛔, 1L, Pembro+QT x QT, fase 3, após 5 anos. Benefício mantido para QT+ IO: OS HR 0,64; ORR 50% (🚩Sqm HR 0,73). jto.org/article/S1556-…

Pooled 5-yr outcomes of Pembro+Chemo for PDL1<1% metastatic NSCLC JTO & JTO CRR:

- 442pts (KN189, KN407 &China/Japan extensions)
- mOS 0.64, mPFS HR 0.66, 5yr OS 12.5 v 9.3% favors chemo-IO
- g3+ TRAEs 59.1% chemo-IO

IASLC OncoAlert Shirish Gadgeel
#LCSM
jto.org/article/S1556-…

We know that radiotherapy is an essential part of the treatment of such aggressive disease, but outcome using 60 Gy in 30 fractions is unsatisfactory.. time for dose escalation?

New treatment options for patients with oncogene-addicted NSCLC focusing on EGFR-mutant tumors.

ASCO Educational book 📖 DOI 👉🏻 10.1200/EDBK_432516

#nsclc #egfr #lcsm

Las marchas a favor de Gustavo Petro Vs. Las marchas en contra de Gustavo Petro

Colombia healthcare protests: Thousands to march against government reforms youtu.be/ycuFKvVgqMY?si…

Hay MUCHA gente

Así reacciona un país a un liderazgo pobre.

Novel EGFR germline mutation in an individual with lung cancer. Germline mutations in lung cancer is a developing paradigm with the potential to change screening guidelines.

Himil Mahadevia Janakiraman Subramanian Saint Luke's Cancer Institute Ben Ponvilawan Clinical Lung Cancer

clinical-lung-cancer.com/article/S1525-…

The IASLC Lung Cancer Staging Project: Proposals for Revision of the Classification of Residual Tumor after Resection for the Forthcoming (9th) Edition of the TNM Classification of Lung Cancer - Journal of Thoracic Oncology jto.org/article/S1556-…

Esto es la ciudadanía pidiendo respeto, una imagen dice mucho más que cualquier verborrea ideológica…

Y sin tarima pagada por nosotros para que el M19 conmemore sus delitos

Presente con las Sociedades Científicas y ACRO . Por nuestros pacientes NO podemos permitir que acaben con la salud y el
país