Gotta love this work by Shingo Kajimura Lab in Cell discovering the importance of #bcaa metabolism in brown adipose tissue (BAT) mitochondria and highlighting functions of BAT beyond thermogenesis. cell.com/cell/fulltext/…

Congratulations, Katsu!

Beautiful work from Martin. Jastroch lab in Science Magazine on evolution of UCP1 in #adipose #thermogenesis from marsupials to mammals. Also superb editorial by Katharine Grabek & Sprenger. Two-stage evolution of mammalian adipose tissue thermogenesis | Science science.org/doi/10.1126/sc…

Role of lipids in interorganelle communication dlvr.it/T8BD9j

Special Symposium "Molecular Metabolism",  celebrating 40 years of the Saltiel Lab Saltiel lab This Friday, July 19 1:00-5:30pm Garren Auditorium, BSB on the campus of UCSD

Excited to share our new preprint! A pilot study aiming to address underlying metabolic defect in hyper-IgD syndrome caused by mevalonate kinase deficiency. Amazing collaboration with Anna Sediva and Prague Immunodeficiency Group WashU Endocrinology, Metabolism & Lipid Research Test Account. Check it out!👇 medrxiv.org/content/10.110…

Congrats again, Alan! It was a wonderful gathering with great science. Really happy to see everyone.

Our latest @iScience paper is now published. Our findings support that human BAT clears BCAA faster than other subcutaneous adipose tissue depots, while BCAA uptake in BAT is lower in people with obesity and T2D. Many thanks to the all the co-authors! cell.com/iscience/fullt…

Human UCP1 is less sensitive to GDP inhibition 🥁 doi.org/10.1111/apha.1…

Here is our new paper showing that beige fat cells occur in 2 major types: UCP1-high and Futile creatine cycle (FCC)-high. This kind of reconciles the UCP1 vs FCC discussions. authors.elsevier.com/a/1jWGh5WXUlWk…

Central activation of catecholamine-independent lipolysis drives the end-stage catabolism of all adipose tissues biorxiv.org/content/10.110…

Thrilled to share our new paper in Nature Communications! 🌟 Adipocytes can directly sense light via photoreceptors, unveiling a novel adipose-hypothalamus crosstalk through histidine. Read here: rdcu.be/dQovk #Science #Research #Metabolism

Now published! Stephen Decker and I discuss potential biophysical mechanisms by which membrane lipids influence OXPHOS. Cell Metabolism cell.com/cell-metabolis…

Really excited to share our latest paper describing the MitoLuc assay for quantitative mitochondrial protein import, which we wrote in collaboration with Ian Collinson! sciencedirect.com/science/articl…

Big shout out to Jon Brestoff and Stella Varnum for this fascinating study on mitochondria transfer as a therapeutic strategy in treating inherited mitochondrial diseases!

A new viewpoint from Rosen and Kajimura Journal of Clinical Investigation BIDMC "For now, however, we believe that the community should approach the notion that inflammation is the driver of #insulin resistance in humans as a hypothesis, rather than a proven fact" jci.org/articles/view/…?

🚨After 8y and many dead ends- we are excited to clarify how "stable" adipocyte lipolysis is potently activated independent of catecholaminergic signals while being restrained by glucose and insulin. RT and feedback welcome as we work from preprint to pub! biorxiv.org/content/10.110…

Happy to share our collaborative review in Nature Reviews Cardiology on #lysosome #immunology #metabolism & #atherosclerosis. Fun working with European colleagues Fabrizia Bonacina Giuseppe Danilo Norata Yvancharvet Laurent. All started when met at Athero 2023 Gordon Research Conferences in Barcelona! nature.com/articles/s4156…