Research|Tuz et al report that #stroke and #MyocardialInfarction induce the release of neutrophil extracellular traps (NETs), loss of B cells and reduced IgA secretion, and that inhibition of NETs prevents loss of IgA in patients and mice. Institute for Experimental Immunology & Imaging
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Research Highlight on the study by Weinstock, Gopakumar, Burugula et al. in nature, where the authors show that aberrant TCL1A activation is a common mechanism shared by #ClonalHematopoiesis sustained by multiple mutations. doi.org/10.1038/s44161…

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Research Highlight | Grune et al. in Circulation show that immune activation in acute respiratory distress syndrome (ARDS) induces shifts in #cardiacmacrophages like those observed in individuals with #COVID19 . nature.com/articles/s4416…

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Research| Hu et al. describe how histone H1.0 regulates cellular responses to mechanical stimulation, inducing #myofibroblast activation and coupling force generation to nuclear organization and #genetranscription .
doi.org/10.1038/s44161…

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News&Views | Walsh & Kipnis discuss the study by Yin, Zhang and Lee et al. published in nature , where the authors show how different eye compartments respond to immune stimuli and how this affects #BrainImmunity .

doi.org/10.1038/s44161…

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Research| In a PCORI-funded study examining the effectiveness of #diabetes drugs in adults at moderate risk for CVD, GLP-1RA and SGLT2i reduced the risk of CV events compared to DPP-4i, while sulfonylurea increased it.
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News&Views| Qin, Huang & Moslehi discuss the study by Aguilar et al. revealing the involvement of the #PD1PDL1 immune checkpoint in neonatal heart regeneration. doi.org/10.1038/s44161…

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❤️Our March issue is out❤️ Discover two antibiotics that promote #CardiacRegeneration , find out how the response of liver macrophages to hyperlipidemia drives #atherosclerosis , learn about BRD4 as a regulator of #cardiomyocytes differentiation, and more!

nature.com/natcardiovascr…

Perspective | Ryan & Roberts make a case for the importance of #iPSCs models to improve our understanding of inherited #arrhythmias .
doi.org/10.1038/s44161…

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Research| Antila et al. show that brain amyloid- β load is not significantly affected by sustained #meningeallymphatics vessel atrophy or hyperplasia induced by lymphangiogenic growth factor manipulation in two mouse models of #Alzheimer .

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Research| Ahmed, Nguyen, et al. identify paromomycin and neomycin as candidates and validate that the combination of these two #antibiotics promotes cardiomyocyte proliferation and improves cardiac function post- #myocardialinfarction . Hesham Sadek
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Research| Brash et al. created the #BulkECexplorer , an online tool to predict active and leaky gene expression in five vascular endothelial cell subtypes commonly used for functional studies. doi.org/10.1038/s44161… @ruhrberglab, UCL Institute of Ophthalmology
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Research| Piollet, Porsch, et al. report that the myeloid receptor #TREM2 limits necrotic core formation in #atherosclerosis and controls key atherosclerosis-related functions of macrophages, such as efferocytosis, lipid uptake, and foam cell survival.
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Research| Di Nunzio, Hellberg, Zhang, Ahmed, et al. identify liver macrophages as key cells that organize the systemic responses to #lipoproteins during the initial phases of #atherosclerosis pathogenesis doi.org/10.1038/s44161…
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Horitani and Chavkin et al. report that loss of the Y chromosome in macrophages correlates with fibroblast activation in the myocardium and deficiency in the #epigenetic regulator Uty increases fibrosis and #CardiacDysfunction .
doi.org/10.1038/s44161…

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Research Highlight on the study by Pane et al. published in Circulation Research, where the authors reveal the role of calcineurin as an #epigenetic regulator of #CardiacHypertrophy

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Research | Vargas Aguilar, Cui, et al. report that the #PD1 / #PDL1 checkpoint inhibitor pathway is highly active in the immune cells of newborn mice, and disruption of this pathway impaired #heartregeneration . Stefi Vargas, Eric N. Olson, @UTSWNews
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Research| Jiang and Gao et al. identified that accelerated biological aging measured by clinical traits hints innovative clues for subclinical prevention of cardiometabolic multimorbidity and mortality. Peking University, Harvard T.H. Chan School of Public Health
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Research| With a genome-wide #CRISPR screen in #iPSC , the authors identify the acetyl-lysine reader BRD4 as a regulator of cardiomyocyte differentiation that they subsequently validate in vivo PennCVI Gladstone Institutes UPenn CDB Penn Epigenetics UCSF Cardiology
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