Structural biology and pharmacology meets nephrology and genetics
Calcium sensing receptor is the main GWAS hit for serum calcium —> cryo EM structure —-> drug Cinacalcet —> patient benefit ( please play on repeat 🔁)

Thank you Katalin Susztak for yours and Penn/CHOP KIC’s support (and for snapping the photo 👇)!! Amazing group of KDSAP Penn Arts & Sciences undergraduates who nailed their presentations today!

cc: Penn Kidney CHOP Pediatric Nephrology

Refining the impact of genetic evidence on clinical success. The clinical success are close to 3x better. So the Susztaklab will continue the 🧬 -> 🧫 ->💊 for 🫘 ⁦nature⁩ nature.com/articles/s4158…

Please join our Penn/CHOP KIC seminar series tomorrow. Our Penn Arts & Sciences undergrads will be sharing their work.

Congrats to all pilot awardees Penn IDOM Parker Wilson Theodore G. Drivas 🏳️‍🌈 Juan Alvarez Marie Guerraty MD, PhD

No better time to share our 🔥🆕📜 The key role of altered tubule cell lipid metabolism in kidney disease development Kidney International kidney-international.org/article/S0085-… Lauren Elizabeth Lee (she/her) Tomohito Doke Dhanunjay Mukhi

Dr. Mitchell Lazar is the 2025 recipient of the George M. Kober Medal from the Association of American Physicians (AAP)—the AAP’s highest honor—recognized for pioneering contributions to #diabetes and metabolic research. Penn IDOM spr.ly/6019wfLXl

New from Mitch Lazar An unanticipated, non-canonical activation function of NCoRs that is required for metabolic health Nature Metabolism Penn IDOM nature.com/articles/s4225…

Finishing the week with some awesome double rainbows 🌈

FINALLY OUT! Our work using spatial and single-cell transcriptomics to characterize the human immune response in pig-to-human kidney xenotransplantation is now published Nature Communications
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nature.com/articles/s4146…

Excited to share our work on a new regulatory mechanism of kidney tissue regeneration by macula densa cells led by Georgina Gyarmati
jci.org/articles/view/…

We're excited to announce this workshop co-organized with NIDDK, Innovative Science Accelerator Program and Tissue Morphodynamics Group featuring kidney and other epithelial organ speakers. We hope to highlight rapidly expanding research opportunities in kidney engineering & welcome new researchers!

Cloudy Solar eclipse

Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis | Science Advances Andreas Linkermann science.org/doi/10.1126/sc…

X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements - including ACSL4 ⁦Nature Communications⁩ by CKDGen ncbi.nlm.nih.gov/pmc/articles/P…

Excited to learn from the amazing Dr Mitch Lazar #cicrcadianrhythms ⏰& biology 🧬 ⁦ #AAP /ASCI/APSA joint meeting!!

Genetics of cystogenesis in base-edited human organoids reveal therapeutic strategies for polycystic kidney disease: ⁦Cell Stem Cell⁩ ⁦Beno Freedman⁩ cell.com/cell-stem-cell…

Pragmatic Trial of Hospitalization Rate in Chronic Kidney Disease | ⁦NEJM⁩ nejm.org/doi/full/10.10…

Time to sound the alarm about the hidden epidemic of kidney disease ⁦nature⁩ nature.com/articles/d4158…

Congrats to Safaa Hammoud on this work! Deleting CPT1A had surprisingly mild phenotype. May point to important role of peroxisomes in fatty acid oxidation? Great collaboration with Ben Humphreys and Irfan Lodhi in WashU Endocrinology, Metabolism & Lipid Research and others!!