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Analysis of increased platelet activation in people with #T1D Diabetologia link.springer.com/article/10.100…

Well before the new entrants arrive, competition and hopefully better more affirdable pricing, is well underway for existing GLP-1 medicines #obesity prnewswire.com/news-releases/…

An unrecognized role of fasting-induced ketogenesis in antibiotic treatment suggesting a potential ketone body-based treatment strategy for antibiotic sensitization for Rx of bacterial sepsis Cell Metabolism cell.com/cell-metabolis…

A protective INS SNP causes accelerated IRE1α-dependent decay of insulin mRNA, resulting in alleviation of ER stress and reduction of beta-cell immunogenicity thereby protecting against #T1D #Genetics Cell cell.com/cell/fulltext/…

Hepatic lipid droplet cholesterol reduction identified as a potential therapeutic target for #MASH PNASNews pnas.org/doi/10.1073/pn…

KYNA acts through the GPR35 receptor to inhibit vagal afferent signaling and subsequently activate ARCAgRP neurons, which leads to increased food intake #microbiota Cell Reports cell.com/cell-reports/f…

In 2 cases Tirzepatide shows great effectiveness with regard to body weight, MASLD and insulin resistance in Alström syndrome #obesity academic.oup.com/jcem/advance-a…

Starting, stopping restarting medicines #T2D in Sweden Diabetologia link.springer.com/article/10.100…

Towards optimizing #cancer therapy with a #microbiota lens Nature Metabolism nature.com/articles/s4225…

Here neuronal CCL2 is specifically increased by hyperglycaemia and contributes to anxiety disorders, providing additional insights into the link between #diabetes and mental health disorders Nature Metabolism nature.com/articles/s4225…

The potential of Cagri-Sema to be explored in ongoing trials #weightloss #diabetes #obesity Novo Nordisk novonordisk.com/content/dam/nn…

As the small molecule oral GLP-1 RA class moves forward led by orforglipron studied in the ACHIEVE and ATTAIN trials, oral semaglutide 25mg daily may be the first oral GLP-1 medicine approved for #weightloss #obesity U.S. FDA novonordisk.com/content/dam/nn…

Keeping an eye of the safety of semaglutide #weightloss #T2D #obesity An update on NAION nature.com/articles/s4143…

Elegant studies in mice link aspartame to accelerated #atherosclerosis through enhanced #insulin action. cell.com/cell-metabolis… Yet in humans #T2D insulin Rx in the ORIGIN trial was not linked to increased rates of #heartdisease nejm.org/doi/full/10.10…

How far can GLP-1 medicines go to add value on top of existing anti-inflammatory therapies? Is #weightloss necessary? Multiple trials are underway to provide answers healio.com/news/rheumatol…

The liraglutide for children/adolescents #obesity trial SCALE Kids has generated letters to the Editor @nejm with various reservations and queries ”In the past, physicians rationalized prescribing addictive drugs for pain and enabled the opioid epidemic” nejm.org/doi/full/10.10…

The mitogen RSPO1 promotes β cell neogenesis in mice and could therefore represent “an unprecedented hope in the continued search for #diabetes alternative therapies” cell.com/cell-reports-m… Cell Reports Medicine

Sucrose- #microbiota interactions and SREBP-1c are required for DNL and hepatic steatosis in the absence of dietary fat sciencedirect.com/science/articl… Molecular Metabolism