Collaborative work at @LabRoussos, Voloudakis Lab and Hildebrandt Lab performs the first GWAS in binge-eating disorder in the Million Veteran Program. Congrats to David, Trevor and Georgios for driving this project! medrxiv.org/content/10.110…

The first GWAS of binge eating disorder identifies loci near HFE, MCHR2 and LRP11. At the HFE locus, one of the risk variants is the hemochromatosis variant thereby linking iron overload with bing eating (looks like the opposite of iron deficiency and pica). Fascinating!

I’m happy to share a preprint of our new GWAS of depression, identifying 64 new risk loci, refining the genetic architecture and predicting risk of recurrence and comorbidities. medrxiv.org/content/10.110…

Excited to share our #singlecell multi-cohort dissection of the transcriptome in #Schizophrenia medrxiv.org/content/10.110… with Brad Ruzicka Shahin Mohammadi @FullardJohn Manolis Kellis

Big congrats to #TimBigdeli Georgios Voloudakis and many other collaborators for the recent paper describing Penetrance and Pleiotropy of Polygenic Risk Scores for #Schizophrenia, #bipolardisorder , and #depression Among Veterans using the #MVP and #CSP572 cohorts

Finally, congrats to Georgios Voloudakis for leading the collaboration with Anders Børglum Manuel Mattheisen and colleagues on the shared and differentiating genetic architecture for #Autism and #ADHD Nature Genetics go.nature.com/3LRKRxq

Today Regeneron Genetics Center celebrates the publication of genetic discovery and functional validation of ANGPTL7 as a highly promising drug target for glaucoma. nature.com/articles/s4200…

We would like to share with you our recently published article “Identification of shared and differentiating genetic risk for autism spectrum disorder, attention deficit hyperactivity disorder, and case subgroups.” rdcu.be/cWmMA… Details below.

The website for the Center for Disease #Neurogenomics is LIVE! Led by Panos Roussos, this is one of few centers in the world w access to brain tissue & population-level datasets. Learn more: icahn.mssm.edu/research/neuro… Friedman Brain Institute Icahn School of Medicine at Mount Sinai Icahn Genomics Institute Mount Sinai Institute for Genomic Health

Its 6 groups: Multi-omics Technology @FullardJohn Multi-omics Data Integration Jaroslav Bendl Computational Neuroepigenomics Kiran Girdhar Statistical Neurogenomics Gabriel Hoffman Single Cell Neurogenomics Donghoon Lee Translational Bioinformatics & Precision Therapeutics Georgios Voloudakis

Better late than never. Happy and relieved to share a final published version of one of my PhD projects in which we uncovered a fascinating genetic link between language ability, psychiatric risk and creativity. 🧵 nature.com/articles/s4159…

Phenotype misclassifications in the GWAS cohorts dilute effect sizes and reduce statistical power. Here the authors describe a statistical approach to quantify and adjust for effect size dilutions in GWAS meta-analysis. Interesting! medrxiv.org/content/10.110…

New GWAS of ADHD based on 38,691 cases and >180k controls. Congrats! Ditte Demontis, Anders Børglum, iPSYCH and collaborators. 🧵 nature.com/articles/s4158…

First GWAS of binge eating disorder using machine learning-based EHR phenotype Nature Genetics. One of the GWAS hits is hemochromatosis variant C282Y in HFE implicating iron metabolism in disease etiology. Congrats Panos Roussos Georgios Voloudakis and team. nature.com/articles/s4158…

Excited to share the first GWAS of binge eating disorder using #MVP from @BursteinPhD TrevorGriffen Georgios Voloudakis at #CenterDiseaseNeurogenomics Mount Sinai Psychiatry Mount Sinai Genetics Friedman Brain Institute Icahn School of Medicine at Mount Sinai that was published in Nature Genetics nature.com/articles/s4158…

And further discussed in a news and views article Nature Genetics by Jackson Thorp et al. nature.com/articles/s4158…

🎉 Excited to announce preprints from the first #PsychAD package! Check out details of our work at Psych-AD.org 🧵 Found out summary of papers below👇

.Georgios Voloudakis et al. show statistically significant, but weak, associations between occupational categories and genetic risk scores for psychiatric disorders. nature.com/articles/s4156…

Association of polygenic scores for neuropsychiatric traits with self-reported professions based on analysis of 420k individuals from UK Biobank and Million Veteran Program. Look at the 'arts & design' category. Artistic talent comes at a cost--a piece of your mind :) Voloudakis

Study explores link between people's professions and their genetic predisposition to neuropsychiatric traits medicalxpress.com/news/2025-01-e…