Excited to share our recent preprint with multi-regional RNAseq and ATACseq profilings to explore the differences among brain regions and better understand disease heritability. Panos Roussos @LabRoussos biorxiv.org/content/10.110….

Very excited to share work from @LabRoussos Mount Sinai Genetics Mount Sinai Psychiatry Friedman Brain Institute that was published this week Nature Neuroscience Nature Genetics.

🔥 HOT OFF THE PRESS Nature Genetics 📰 Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains 👩🏾‍🤝‍👨🏿 Anders Børglum Ditte Demontis and team ⬇️ go.nature.com/3WGYLWI

Our new software dreamlet scales differential expression analysis for single cell data: doi.org/10.1101/2023.0… Checkout the R package: diseaseneurogenomics.github.io/dreamlet

Our spatio-synteny paper finally out in iScience! Excellent collab with Simakov team in Vienna doi.org/10.1016/j.isci…

Thrilled to share our human genetics discovery of the protective association between rare variants in CHRNB2 (encoding a subunit of nicotinic acetylcholine receptors) and smoking addiction, now out in Nature Genetics. See the reply for a detailed thread. Below is a short summary.

Excited to share the first GWAS of binge eating disorder using #MVP from @BursteinPhD TrevorGriffen Georgios Voloudakis at #CenterDiseaseNeurogenomics Mount Sinai Psychiatry Mount Sinai Genetics Friedman Brain Institute Icahn School of Medicine at Mount Sinai that was published in Nature Genetics nature.com/articles/s4158…

"Excited to share our latest preprint from @LabRoussos on to-date largest cell-specific ATAC-seq dataset generated from the PFC and ACC regions” medrxiv.org/content/10.110… Jaroslav Bendl

As part of an int'l team of researchers creating a detailed atlas of human brain cells, Icahn School of Medicine at Mount Sinai's Dr. Panos Roussos, et al. have constructed the First “Multiome” Atlas of Cell Development in Human Cerebral Cortex From Before Birth to Adulthood.👉 tinyurl.com/y6wesubv

We are thrilled to share a preprint on human myeloid cells and AD. Collaboration with Panos Roussos @FullardJohn Christian Porras @collin_spencer_ Milos Pjanic Philipp Weiler and many others.

Thrilled to share our latest research in Nature Communications on idiopathic Parkinson’s disease! 🧠 Grateful for the amazing collaborative effort!🙌 Feng He (Feng HeFeng) Check it out! doi.org/10.1038/s41467…

🎉 Excited to announce preprints from the first #PsychAD package! Check out details of our work at Psych-AD.org 🧵 Found out summary of papers below👇

🧠 New brain atlas reveals region-specific gene regulation & promoter-isoform insights, advancing neuropsychiatric disorder research & genetic fine-mapping. #Genomics #Neuroscience #cdneurogenomics #roussoslab Read more in #NatureCommunications rdcu.be/d06ta

Did you know it takes an average of 8 years to diagnose #BipolarDisorder? Newly published research from the Psychiatric Genomics Consortium (bit.ly/3JkuokY) aims to improve this by learning more about the condition’s biology. Now in Nature: go.nature.com/3PJhi3W

Excited to share our latest review in Trends in Genetics cell.com/trends/genetic…

Excited to share a new study mapping postnatal human brain development with multi-omic single-nucleus data rdcu.be/eabgy 🧠 101,924 nuclei | 4 regions | 10 donors | 5 key stages 🧬 Cell-type GRN linking GWAS loci to 1,149 genes ⚡ Oligodendrogenesis & brain disorders

Congrats Tereza Clarence for the “Multiomic single-cell profiling identifies critical regulators of postnatal brain” now published in Nature Genetics Mount Sinai Psychiatry Friedman Brain Institute Mount Sinai Genetics Center for Disease Neurogenomics nature.com/articles/s4158…

So incredibly excited to be able to officially highlight the outstanding work of Sasha L. Fulton, a previous superstar PhD student in my lab and now a superstar postdoc in the Ishmail Abdus-Saboor lab at Columbia (also an HHMI Hanna H. Gray Fellow), now out at Neuron !!