Very excited to share that I recently started at Ionis as Director in Human Genetics with a vision to establish a human genetics group that integrates into their drug discovery and development pipeline!

"Who wants to coordinate the seminars next year?"

We are thrilled to share our work on microglial genetic regulatory landscapes in Alzheimer’s Disease. Check out our key findings and thanks to all involved! Friedman Brain Institute Mount Sinai Genetics Mount Sinai Psychiatry Icahn School of Medicine at Mount Sinai #MicrogliaADgwas doi.org/10.1038/s41588…

Big congrats to pengfeiDong and many others @LabRoussos and our collaborators for putting together the multi-regional RNAseq and ATACseq atlas in adult human brain biorxiv.org/content/10.110…

I am super excited to announce that our new review on "how a massively parallel reporter assay (MPRA) can be used to interrogate variant function" is finally out! jneurodevdisorders.biomedcentral.com/articles/10.11…

Thrilled to share our study in Nature Genetics on population-level analysis of transcribed enhancers. Thanks to my colleagues at @LabRoussos and reviewers for helping to improve it. nature.com/articles/s4158…

The website for the Center for Disease #Neurogenomics is LIVE! Led by Panos Roussos, this is one of few centers in the world w access to brain tissue & population-level datasets. Learn more: icahn.mssm.edu/research/neuro… Friedman Brain Institute Icahn School of Medicine at Mount Sinai Icahn Genomics Institute Mount Sinai Institute for Genomic Health

A 🧵 on some of my intuitions/priors about the genetics of complex and molecular traits in humans (i.e. what I think of as typical), largely motivated by GWAS/QTL studies over the past decade [citing papers with nice figures where possible]

The Center for Disease Neurogenomics (CDN) had a successful retreat day. The year 2024 marked the 10-year anniversary of the lab, and we have grown to 67 members. #CDN #retreat

Amazing retreat!

For the lifespan single-cell atlas of the human DLPFC, we reveal age-specific gene expression, neuron resilience, glial vulnerability, and circadian reprogramming, offering insights into brain health and disease risk from development to aging. #PsychAD