Efficient metabolism calls for high oxygen consumption, but estrogen (which lowers metabolism) also increases oxygen consumption.

Estrogen causes hypoxia, irregular blood flow, water retention, and excitotoxicity. Progesterone blocks these effects.

CREATINE BENEFITS 101 ⛩️🧘🏽

•Creatine: DHT Boost
•Myostatin Inhibition: Muscle Growth
•Androgenic, Ergogenic,NeuroProtect
•Phosphocreatine: ATP Buffer
•Excitotoxicity Prevention
•Mitochondrial Biogenesis
•Blood-Brain Barrier Protection
•Dopamine Boost: Mood…

Oxidative Stress causes #depression through inducing

(A) Mitochondrial impairment
(B) Nuroinflammation
(C) Glutamate excitotoxicity
(D) BDNF/TrkB dysfunction
(E) 5-HT deficiency in the brain
(F) MGB disturbance
(G) HPA axis dysregulation
#mentalhealth

Excitotoxicity_01 nice and cozy on Exchange Art and linked in bio. Sound on 🔊. Enjoy the chaos and eventual harm it will cause when you can't look away but you won't notice anyway.

¹) Pu-er really is is a herbology powerhouse with a plethora of benefits (All science backed)

- Contains phytoestrogens which balances estrogen/E²
- Heals mucosal lining of the gut
- Neuro-protective against excitotoxicity by inhibiting mGluR⁵
- Anti-Cancer by inducing…

Nicotine, a principal additive compound for tobacco users, is thought as a candidate to attenuate amyloid-β-mediated neurotoxicity and NMDA-induced excitotoxicity…. studies demonstrated that nicotine exerted this neuroprotective action on oxidative stress. Intra-workout no. 27s.

Memantine: An Underutilised Agent in Psychiatry 🚀💊

Find out why 👇

MOA 👉reducing NMDA excitotoxicity due to glutamatergic over-activation 🧠

NMDA receptors' locations: 🧠

1. DLPFC: Influences executive function

2. Ventral Tegmental Area: Houses dopaminergic neurons,…

7) TAURINE

Taurine helps reduce excitotoxicity like agmatine & magnesium due to its GABAergic & glycinergic properties

When you take these 3 together, the jitters/anxiety from Adderall are kept to a minimum

But on top of that, it's going to significantly reduce mitochondrial…

And if that wasn't enough for you.

They also enhance:

- Neuro-protection against excitotoxicity by inhibiting mGluR⁵
- Neurotransmitter release such as GABA + Dopamine

Two acute gut-healers.

Haven't been this bullish on compounds since BPC157.

6) Agmatine

Like Magnesium, Agmatine reduces glutamate excitotoxicity via NMDA antagonism

On top of that, it’s probably the most neuroprotective nutrient you can take

- Boosts BDNF (rapid antidepressant)
- Strengthens blood-brain barrier
- Restores brain insulin signaling
-…

Congratualations to Creighton Research Assistant Elyssa Pereyra for her poster: Glucocorticoid Treatment Protects Inner Hair Cell Ribbon Synapses from Degeneration following Kainic Acid-Induced Excitotoxicity in Neonatal Mouse Cochlear Explants
#ARO2024

A guide to cell death pathways

#Apoptosis
#Necroptosis
#Pyroptosis
Autophagic/Lysosomal cell death
#Ferroptosis
#Entosis /Cell Cannibalism
#Excitotoxicity /Ion disequilibrium

Inhibiting/Activating specific modes of death to treat human disease

Archived for learning & writing…

Founders and creators are obsessed with more.

Trying to maximise every minute.

But what if this obsession is backfiring and actually sabotaging your success?

Never wanting to waste a moment could be leading you towards a dangerous condition known as Excitotoxicity.

It's so…

More than likely, Excitotoxicity_02. A rather disgusting continuously running feedback loop that corrupts itself.

Neuroprotection / anti-excitotoxic:

Nicotine exerts neuroprotective effects through reducing glutamate excitotoxicity in several regions of the brain, including the hippocampus.

This may help to explain positive neuropsychiatric benefits in conditions such as schizophrenia,…

I did everything i could today to reduce sensory excitation and not trigger eye and brain pain.

Shades inside, stayed in the dark, used dark screens and low brightness, took herbals to lower glutamate excitotoxicity such as cats claw, ginko, ashwaghanda and neuro prep…

10/ Glutamate excitotoxicity can start 'a cascade of neurotoxicity,” leading to the loss of neuronal function and cell death, which then leads to neurodegenerative diseases doi.org/10.3389/fncel.….

Australian Study Finds That Those With Post COVID Cognitive Issues Are Likely To Suffer From Blood Brain Barrier Disruption And Glutamatergic Excitotoxicity!

thailandmedical.news/news/australia…
#COVID19 #News #SARS CoV2 #SARS #LongCovid #Brain #America #USA #France #England #Thailand #Canada

Now I know where excitotoxicity comes from. Dave Meier

9/ Why is that important? Astrocytes control the glutamate (a neurotransmitter) released at the synapses. They optimize neuronal functions and prevent “glutamate excitotoxicity” – a prolonged or exacerbated activation of glutamate receptors doi.org/10.3390/cells8…