A guide to cell death pathways

#Apoptosis
#Necroptosis
#Pyroptosis
Autophagic/Lysosomal cell death
#Ferroptosis
#Entosis /Cell Cannibalism
#Excitotoxicity /Ion disequilibrium

Inhibiting/Activating specific modes of death to treat human disease

Archived for learning & writing…

Entosis, the process where one cell invades another, is a mechanism that takes place in some tumors.

Here, researchers investigate the role of Ca2+ in the entotic process and how it can be exploited to treat entosis-associated cancers.

👉ow.ly/x1hM50Nr9nn

Permanents with a surfeit of atypical mitoses, cell cannibalism (i.e., entosis), monstruocellular pleomorphism, and necrosis.

Akshar Rao Rosenblatt Lab Buzz Baum's Lab Levayerlab Eduardo Moreno Eugenia Piddini Benoit Ladoux In cancer, entosis involves high deformability tumor cells engulfing and outcompeting less deformable neighbors, controlled by RhoA and actomyosin. twitter.com/EpiMechFC/stat…

Sun, Q., Luo, T., Ren, Y., Florey, O., Shirasawa, S., Sasazuki, T., Robinson, D. N., & Overholtzer, M. (2014). Competition between human cells by entosis. Cell Research, 24(11), 1299–1310. #EpithelialMechanics
nature.com/articles/cr201…

<Technical Note: there appears to be an open Entosis Link port on this structure.>

I knew I had forgotten to pack something!

1 : Entosis vs Cannibalism
2&3 : Entosis

Sources :
nature.com/articles/s4156…

ncbi.nlm.nih.gov/pmc/articles/P…

My question how synthetic cells are removed. Four terms might be helpful. Each one describes a different disposal. Apoptosis, autophagy, necrosis, and entosis. Synthetic cells have a different composition. Maybe selected with a very foreign selection.

youtube.com/watch?v=n4ImIN…

In Gastroenterology:
Cell-in-Cell-Mediated Entosis Reveals A Progressive Mechanism in #PancreaticCancer
gastrojournal.org/article/S0016-…
Entosis is a cell-in-cell phenomenon that is associated with poor prognosis in pancreatic cancer. This study identified NET1, neuroepithelial cell…

Cell-in-Cell–Mediated Entosis Reveals a Progressive Mechanism in #Pancreatic Cancer ➡️ ow.ly/KCZu50QjVGI

Disfrutando de esta transmisión de conocimiento #Tendiendopuentes por Federico Lucantoni Tipos de muerte celular (1). BCL2/BCLXL más resistente, metabolismo mejorado, target en TNBC (2). Cell in cell (3). Muerte celular entotica por palbociclib. (4). Entosis ¿factor pronóstico?

El Dr. Federico Lucantoni ha logrado la ayuda CIGE 2023 grupos emergentes para realizar el proyecto Ento-cáncer: Estudio de la entosis en cáncer humano. El objetivo de este proyecto es encontrar biomarcadores de entosis y avanzar en la caracterización molecular de este proceso.

🚨An interesting form of cell death☠️ : Entosis and cannibalism often look similar on light microscopy🔬

Dan Graham Miruna Popescu, MD and #pathTwitter what do you think? Entosis vs cannibalism?
...More in the tweet below👇🏻

#celldeath #pathX #cytology

I am pleased to share with you our new publication in Cell Death and Disease on the intriguing mechanism of entosis!

rdcu.be/dvT2f

The number of distinct cell death pathways is honestly obnoxious and I refuse to learn cuproptosis on top of apoptosis, necrosis, necroptosis, pyroptosis, parthanatos, PANoptosis, anoikis, ferroptosis, entosis, (NET/MET/EET)osis, ADCD, etc.

Competition between human cells by entosis | Cell Research nature.com/articles/cr201…

ฅNya! Here's the latest 🗞 from [ Advanced Science ]: 'Orai1 is an Entotic Ca2+ Channel for Non‐Apoptotic Cell Death, Entosis in Cancer Development' 🔗: onlinelibrary.wiley.com/doi/10.1002/ad…