40s M Lung mass. Very unexpected findings...

#ThoracicPath #PathX #PathTwitter

New predictive biomarker for gastric cancer - can you identify it based on this pattern of expression? #GIpath #IHCpath #PathTwitter

Dan Graham Under the microscope, a sight to behold,
A stroma so myxoid, cells young and old.
With vessels interspersed, and cells that float free,
A landscape so diverse, in this cardiac sea.

60s M with left atrial mass.

#PathX #PathTwitter #CardiacPath #ThoracicPath

This spinal mass was a tough case (at least for me). The first two pics show a poorly diff component adjacent to a more mod diff area (this area stained positive with brachyury on the biopsy).

Signed out as dedifferentiated chordoma. Very cool.

#PathTwitter #BSTPath

#slidearchiveseries clear cell adenocarcinoma of urinary bladder #gupath #pathtwitter

🔬solid, tubulocystic, and papillary growth patterns; hobnail cells with eosinophilic or clear cytoplasm
➕ CK7, PAX8, HNF1β, p53, Napsin
➖ GATA3, p63, ER, PR, WT1

60s F multiple small bilateral lung nodules. Dx, ddx, stains?

#ThoracicPath #PathX #PathTwitter

CD117 strong diffuse +
CK7 scattered single cells
GATA3 neg

Oncocytoma it is! Great job everyone, you nailed it.

IHC panel:
CKAE1/3: positive
calretinin: positive
WT1: weak focal positive
TTF1: negative
desmin: negative
claudin4: negative

Enough to call mesothelioma, or need more meso markers?

60s M 6.5 cm renal mass extending into perinephric fat. What do you think the diagnosis is? Would you get an IHC panel to help resolve any ddx you have?

#GUPath #PathX #PathTwitter

70s F with pleural and pericardial masses/studding as well as innumerable parenchymal lung masses. Bx of pleural mass.

Ddx? Dx? Immunopanel?

#ThoracicPath #PathX #PathTwitter

Challenging conventional belief, we found that atypical spindle cell/pleomorphic lipomatous tumor (ASPLT) can rarely undergo sarcomatous transformation. Excited to share insights on this phenomenon! #bstpath

modernpathology.org/article/S0893-…

Thanks for all the responses. Indeed, the question here is: 'Is it an angiofibroma of soft tissue, or just a vocal cord polyp?' I don't think we'll ever know for sure, as it's not worth doing fusion analysis etc. A beautiful benign case nonetheless!

Cool new applications of GRM1 immunohistochemistry to diagnose chondromyxoid fibroma! #BSTpath #IHCpath #Cytopath

Subcutaneous CMF:
pubmed.ncbi.nlm.nih.gov/36810795/

CMF with FGF23 expression mimicking PMT:
pubmed.ncbi.nlm.nih.gov/38303543/

Cytopathology diagnosis of CMF:
pubmed.ncbi.nlm.nih.gov/38281480/

70s M w/ 1.3cm laryngeal mass near vocal cords. clinically suspicious for neoplasm. Thoughts?

#PathX #PathTwitter

Mediastinal mass in young adult male.

Mixed inflammatory background and Hodgkin/Reed-Sternberg cells.

IHC in next tweets...

#hemepath #pathology

Now this is bone AND soft tissue pathology! #BSTpath

It's calcified, it's chondroid, it's mesenchymal...what's not to like? #BSTpath

pubmed.ncbi.nlm.nih.gov/37102574/

Look out - it's the myxoid, MUC4-positive variant of superficial CD34-positive fibroblastic tumor (PRDM10-rearranged soft tissue tumor) #BSTpath

The fabulous Dr. Miles and her 🔥 poster and data on BRAF- mutated AML at #SCT24
Come talk to her if you’re here.
Linde Miles AK Eisfeld
And a esp. thanks and shoutout to Bobby Bowman for his awesome analysis pipeline.