Spindle assembly checkpoint inhibition as a lethal vulnerability in cancer cells with whole-genome doubling. Two exciting papers in Nature today. nature.com/articles/s4158… and nature.com/articles/s4158…

#ANR2021 was great, novel exciting findings and great talks, thanks to all the speakers, all talks are online for registrants, hope to welcome you at #ANR2022 live in Amsterdam for the REAL THING!!!!

great review on the complex control of fork progression through many factors including FANCJ/BRIP1 DOI:doi.org/10.1016/j.molc…

amazing movie 'cancer and acrobatics’ by Laure youtube.com/watch?v=am7Nlm…

new paper from our team!! MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells. Zanotti S et al. Sci Rep. 2021 Jul 14;11(1):14454. doi: 10.1038/s41598-021-93863-9. PMID: 34262099 nature.com/articles/s4159…

Want to take up a postdoctoral position in the Speleman Lab @GhentUniversity to explore replicative stress as novel drug vulnerability in childhood neuroblastoma. Apply through the UGhent e-recruitment tool before August 31st 2021.

MYCN activation congests the translational machinery and triggers an ephemeral pre-senescent state in RPE cells. Collaboration with Speleman Lab. #MYCN #Senescence #CellProfiling #Microscopy #CellularHeterogeneity nature.com/articles/s4159…

HTSplotter: an end-to-end data processing, analysis and visualisation tool for chemical and genetic in vitro perturbation screening biorxiv.org/content/10.110…

So excited with the approval of our UGhent GOA REINFORCE program aiming to study the interface of innovative drugging strategies and tumor microenvironment in neuroblastoma. Congrats to all the amazing team members Jo Vandesompele Charlotte Scott @Svennetti Steven Goossens Katleen De Preter

check out our new paper Cancers MDPI deciphering early steps in neuroblastoma formation and critical tumor dependencies, great collaboration with Tom Look and Glenn Marshall labs mdpi.com/2072-6694/13/1…

Want to know more on how copy number changes shape neuroblastoma biology, check out our new review in the latest issue of Journal of Personalized Medicine. mdpi.com/2075-4426/11/1…

VACANCY! Postdoctoral position now open on spatial omics analysis of immune response to novel drugging combinations in neuroblastoma at PPOL lab Speleman Lab UGent Belgium. #postdocugent #cancerresearch #pediatriccancer Wesbite: ppol.be

Senescence is a much more variegated and plastic process than initially anticipated. It may promote relapse but also represent a druggable target in neuroblastoma --- a review by Sofia Zanotti Speleman Lab --- rdcu.be/cHCmn

Check out our newest review by sofia zanotti on senescence in neuroblastoma, as part of a great collaboration with the winnok de vos lab -- Winnok De Vos -- Speleman Lab — rdcu.be/cHCmn

We managed to re-schedule our Keystone Meeting on Targeted Protein Degradation (yet again). New date is November 6-9, 2022. Looking forward to (hopefully) meet friends and colleagues in person. Please note the co-occurring meeting on ubiquitin biology! 👇

Postdoctoral position now open on spatial omics analysis of immune response to novel drugging combinations in neuroblastoma at PPOL lab APPLY at career5.successfactors.eu/sfcareer/jobre… — Speleman Lab --ppol.be

Exited to share our new paper "RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition" opening perspectives for new therapeutic approaches for high-risk neuroblastoma patients science.org/doi/10.1126/sc… CRIG

Excited to share our latest publication "RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition" science.org/doi/10.1126/sc… CRIG

Online Now: Pan-cancer proteomic map of 949 human cell lines dlvr.it/STz6cq

Check out our new paper on SOX11 online in Nature Communications, thanks so much to all our collaborators for their essential contributions. rdcu.be/c64KJ