Let’s play a little game. Let’s say that you’re the CSO at a cancer pharma company, and you have to choose a target to go after. Here’s a gene – high expression is associated with poor prognosis in brain cancer. Looks like a good candidate for an inhibitor right?

Excited to share our CellChemicalBiology lockdown review on reversible covalent and covalent PROTACs! @gbernardes_chem Georg Winter 🔥online now🔥 authors.elsevier.com/a/1cq3c8jWWJlv…

TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules

🚀 Registration for the Probe Hackathon on Sept 23 at Merck KGaA is OPEN! Join us for a day of learning, networking, and contributing to biomedical research. Tour the site, meet experts, and help improve the Chemical Probes Portal. Don’t miss out! #Hackathon #ChemicalProbes

The #ICBS2024, co-organized by Cheryl Arrowsmith and Mike Tyers, is a must-attend event for anyone in chemical biology. Half of the session speakers will be selected from abstract submissions—register by August 31 for a chance to be on stage. Register: chemical-biology.org/event/icbs2024….

Very excited, that we have again been able to put together a high powered lineup covering diverse aspects of early drug discovery for the #LED3Lectures 2024/2025 of the Leiden Early Drug Discovery & Development (LED3). If you are interested, please join us in Leiden!

Quality reagents equals quality and reproducible science. A piece on the antibody situation by Rick Kahn and colleagues. elifesciences.org/articles/100211

Congrats James W. Checco Keriann Backus and Michael Booth on winning this year's ICBS rising star award in chemical biology. Still time to register to hear them speak about their exciting research! chemical-biology.org/page/ICBS2024

Thrilled to catch up with Chris Lima (Memorial Sloan Kettering Cancer Center) today, and looking forward to his seminar this afternoon! If you are in the Dana-Farber Chemical Biology Program and Harvard Medical School school are this PM, consider joining us!

We are hiring! Looking for a #postdoc to join the team in the Nowak Lab to focus on chemical biology in cells and recombinant systems. Excited about protein degradation, small molecule proximity? get in touch! #TPD #InducedProximity #ChemicalBiology nowak-lab.com

In the second CACHE challenge, the top performer hailed from a regional university in Brazil. So happy we created an opportunity that allowed her to show her stuff. Brilliant folks are everywhere - they just need a fair shot. conscience.ca/news/cache-cha…

Announcing CACHE2 results! Crowdsourcing and conventional methods did as well as novel ML. Teams started from 4 fragments in the PDB. We tested their predictions and found double-digit µM hits. This is the state-of-the-art. Structural Genomics Consortium (SGC) Conscience bit.ly/4dTPBzO

Thank you to everyone who joined us in-person and over zoom yesterday for our 4th anniversary event! It was great to hear unpublished stories and have an opportunity to catch up in person!

Next year, HMS will welcome its first class of students to a new master’s program (MMSc in Therapeutic Sciences). Preparing students for careers focused on early drug discovery that translates to new medicines has long been a core goal of the HMS Therapeutics Initiative.

Save the Date - October 9, 2024 at 9AM ET Harvard Medical School's Office for Graduate Education general info session about master’s programs, including Masters in Therapeutic Sciences! Join us and meet my colleagues and me!!! apply.masters.hms.harvard.edu/register/grade…

#Featured Voices: Michelle Arkin, Sara Buhrlage, Ling-Ling Chen, Peng Chen, Jason Gestwicki, Chuan He, Gerald Joyce, Angela Koehler, Milka Kostić, PhD, Jun Liu, Jim Wells on CCB and chemical biology. dlvr.it/TDRfDM

Voices: Albert A. Antolin (he/him), Yimon Aye, Liron Bar-Peled, Elena De Vita, Nata Dudkina, Michael C. Jewett, Hannah Kiely-Collins 🌻🇺🇦, Ralph Mazitschek, and Zhenrun Jerry Zhang define "What is Chemical Biology." dlvr.it/TDRhvs

Happy Birthday - CellChemicalBiology!

Becoming the editor of Chemistry & Biology and relaunching it into Cell Chemical Biology (CellChemicalBiology) in 2016 were FUN! BUT: interacting with thousands of scientists from across the globe was... PRICELESS! With gratitude, Milka sciencedirect.com/science/articl…

As we celebrate CellChemicalBiology's 30th anniversary, I'd like to thank our broad community for contributing to various special issues this year covering many topics enriched by chemical biology. A toast to the highly multi-disciplinary and inclusive field of chemical biology!