Obesity causes sleep apnea

Treat underlying cause—> reduce sleep apnea

Yet another win for GLP-1 receptor agonists

20% weight loss led to dramatic reduction in number of episodes of breathing stoppage at night.
statnews.com/2024/04/17/eli…

Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography. A State-of-the-Art Review just published in #EHJ
European Society of Cardiology European Society of Cardiology Journals #CardioTwitter #atherosclerosis #CCTA Dr. Deepak L. Bhatt Nick Nurmohamed

academic.oup.com/eurheartj/adva…

This is new

Puppies at #ACC24 !

🐶

American College of Cardiology

Maybe the eternal search for an effective HFpEF med is finally over?

Amazing!

Another win for GLP-1 receptor agonists,

now in heart failure with preserved ejection fraction (HFpEF)

Honored to celebrate this dedicated, hard-working group who represent our program at the highest level inside and outside the classroom on #NationalStudentAthleteDay 👊

#FightOnPenn 🔴🔵⚽️

4-weekly infusions of CSL ApoA1 infusions shows no statistical difference in outcomes vs. placebo in reducing 90-day CV events, AEGIS-II trial shows. Download slides from AEGIS-II here: rb.gy/7mi21c

Quite the morning here in New England and our house 💨

Is this a bad time to mention that Bob was prescient on COVID? 🙄

Excellent/transparent interview by Brad Loncar BiotechTV of Sek Kathiresan MD re: Verve Therapeutics data. Completely agree with Sek’s assessment here and reasons to move forward with next gen LNP.

Highlights, again, that future of genetic medicines depends on delivery, delivery, delivery!

Today, Verve Therapeutics is announcing updates to our PCSK9 program:

1. voluntarily pausing enrollment in the Heart-1 trail of VERVE-101
2. prioritizing clinical development of VERVE-102 which uses a different LNP delivery system
3. announcing clinical trial application have been cleared…

Phil Needleman’s Ten Commandments of Drug R&D. [new blog] Interesting set of themes for success in R&D. lifescivc.com/2013/03/phil-n…

#Lpa AwarenessDay Join us in 10 minutes Family Heart Foundation for the tweet-a-thon to increase awareness of #Lpa

🚨This is very common!
🚨1 in 5 persons have ⤴️ Lp(a)
🚨Get your Lp(a) checked ✅

Pretty excited for next year.

Two castoffs looking to prove something.

There are only two cholesterol ratios you should care about:

Good:
Non-HDL-C/1

Better:
APOB/1

2023 4Q and YE results Verve Therapeutics

2023: year of spectacular progress with human proof of concept for in vivo base editing PCSK9

2024: year of clinical execution with 3 products in clinical trials

2023
1. in vivo base editing works in humans
2. regulatory path in U.S. with IND…

$1B gift to Albert Einstein College of Medicine - Official

Wow!