New study by DPCG: TIMEPAN trial ⏰ Asymptomatic metastatic PDAC: ▶️Immediate start chemotherapy ⏸️Start when symptoms occur Primary outcome: quality adjusted survival 👩🏼‍⚕️ ➡️Full protocol: pubmed.ncbi.nlm.nih.gov/37897803/

The limited evidence available suggests that delayed start of #chemotherapy once symptoms occur vs. immediate start in asymptomatic patients does not worsen OS while it may preserve QOL. The Oncologist Simone Augustinus OncoAlert #PallOnc #SuppOnc academic.oup.com/oncolo/article…

Pancreascarcinoom is een van de meest dodelijke vormen van kanker, met een 5-jaarsoverleving van minder dan 5%. Toch is er de afgelopen 25 jaar in Nederland veel gebeurd in de zorg voor patiënten met pancreascarcinoom. 👉 buff.ly/3sHHKTp #pancreascarcinoom #kanker

Timing of initiation of chemotherapy in asymptomatic metastatic PDAC? 1⃣ Expert opinion: 67% prefer immediate start of chemo 2⃣ Meta-analysis: limited evidence available - no survival difference, potential QOL benefit delayed start of chemo 3⃣ Protocol: let's wait and see! 🙏

#HoraEst !! Congrats Simone Augustinus thesis #PancreaticCancer DPCG today UvA Amsterdam Thesis here➡️ hdl.handle.net/11245.1/56f4aa… ✅ 13 chapters #pancreas, incl #PACAP1 RCT 🇳🇱 #GAPASURG ✅ 161 co-authors, 16 countries ✅ Timing chemotherapy in asymptomatic M1 disease

Our master-project in print 🤩 🇳🇱 JAMA Surgery ‼️ Main message: 61% of all pancreatic cancer patients does not receive tumor directed treatment! ➡️ This warrants further investigation

In this randomized clinical trial, implementation of 5 best practices in pancreatic cancer care did not improve 1-year survival and quality of life. Findings highlight the need for more personalized treatment options. ja.ma/48gQQVW Marc Besselink

Are you an aspiring young academic surgeon? ⭐️ European Surgical Association (ESA) mentorship program deadline April 1st 🇪🇺 & ESA Next Generation meeting before the conference (incl networking 🙏)! More information: europeansurgicalassociation.org/next-generation #ESA #Leeds #May2024 #BeThere

Very gratefull for winning the YOUPPIE award 🌟 Looking very much forward to presenting at the EPC & meeting all new YOUPPIE Pancreas friends 🙏 ➡️Towards many more future projects with o.a. DPCG and #Pancreas2000 🇪🇺

In this randomized clinical trial, implementation of 5 best practices in pancreatic cancer care did not improve 1-year survival and quality of life. Findings highlight the need for more personalized treatment options. ja.ma/3UcszfV Marc Besselink

Kick off next generation ESA 🇪🇺 👨🏾‍⚕️ Do’s and don’ts during surgical fellowships Sheraz Markar 💵 How to obtain funding for research christiane bruns ⭐️ The road to academic succes #PiereAlainClavien ➡️ All highlighting importance of: mentorship, diversity and perseverance!

It’s a wrap. #europeansurgicalassociation Fantastic start with the next generation of surgeon scientists Simone Augustinus Sheraz Markar Fantastic presentations over the days! Marcel André Schneider and an impressive Gala Dinner! Shahid Farid Peter Lodge Uniklinikum Tübingen

Last day - Spread the word 💜💜👇👇‼️ Ana Dugic Lumír Kunovský Sara Nikolić Cecilie Siggaard Knoph Simon Sirtl Simone Augustinus Thomas Hank, MD Lucía Guilabert Daniel Hughes @vasyb Martyn Stott

Two lectures, one message: input of female hpb surgeons is increasing IHPBA E-AHPBA AHPBA #APHPBA: but not enough! Bill Jarnagin, in his presidential address & Rebecca Minter: ➡️We need female presidents⬅️ #LetsDoIt Isabella Frigerio Julie Hallet Melissa Hogg Aiste Gulla

How do the use and outcome of Minimally invasive Whipple compare between 🇺🇸 🇳🇱🇩🇪🇸🇪? Gapasurg.com Nine de Graaf Big differences! Highest use in 🇳🇱 17%, lowest in 🇸🇪 0.1%. Conversion rates lowest in 🇳🇱, especially robot 9%. #IHPBA24

🗣️TOMORROW THURSDAY JUNE 27th‼️ 🔥1️⃣0️⃣:0️⃣0️⃣🔥@ #EPC2024 The amazing💥 YOUPPIE awardees Simone Augustinus and Thomas Hank, MD will give their talks🏆 👉 BE THERE 💜💜💜!!!!!!!!!!!!!!

Very honored to give the YOUPPIE Pancreas award 🏆presentation at #EPC2024: looking beyond trial results in pancreatic research ⭐️ Key points: 1️⃣ Improve international comparison 2️⃣ Use of alternative RCT designs 3️⃣ Importance of implementation DPCG

In AnnalsSurgOncology, #GAPASURG study 🇺🇸🇨🇦🇩🇪🇳🇱🇸🇪 with 2924 #PancreaticCancer patients on DP-PVR vs. standard DP. DP-PVR 🟰 ⚠️associated with ⬆️ in-hospital/30d major morbidity (24% vs. 18%); ⬆️CR-PPH (10% vs. 3%)🩸; ✅NOT associated with in-hospital/30d mortality (1.7% vs. 1.2%).

💡LIDOPAN study: multicenter pilot trial 💉 IV lidocaine for patients in pain with PDAC and CP 👥30 patients, NRS >4 📈 No overall clinically relevant pain reduction day 1 🤩 31% positive effect, lasted op to a month ncbi.nlm.nih.gov/pubmed/39163321 ACG_CTG

How big are the differences in the use, outcome Lap/Robot 🤖 #Whipple between 4 registries 🇺🇸/🇨🇦, 🇩🇪, 🇳🇱, 🇸🇪? #GAPASURG ▶️ Very large differences among 3328 pts in the use of MIPD: 🇺🇸🇨🇦7%, 🇩🇪4%, 🇳🇱17%, 🇸🇪0.1% and rapidly changing still ▶️in-hospital/30-day mortality 🇺🇸🇨🇦2%,