Our multi-population GWAS paper on Afib is online now Nature Communications We identified more genetic loci, population-specific genetic correlations, improved polygenic risk score, and enhanced risk prediction by integrating a PRS and protein score. nature.com/articles/s4146…

Delighted to collaborate on this study led by Jie Liu Kelly Bolton MD PhD describing how germline genetic variation influences the trajectory of clonal hematopoiesis to hematologic malignancy nature.com/articles/s4158… Nature Genetics

A description of the Human Phenotype Project (HPP), a growing dataset of >13,000 participants (already 28,000 have provided consent for enrollment) that aims at dynamic multi-modal deep phenotyping to better understand health & disease risk👇

What proteins mediate #smoking and #AAA risk? Please read our fresh paper in ATVB: An AHA Journal Scott Damrauer PennSurgery Penn Medicine Karolinska Institutet ahajournals.org/doi/10.1161/AT…

Thank you TCTMD for covering our PREVENT validation efforts across Mass General Brigham Mount Sinai Health System Penn Medicine Vanderbilt Health collaboration by Pradeep Natarajan Ron Do Scott Damrauer Quinn Wells

Delighted to contribute to this review spearheaded by D. Patel & Dinesh Kalra, MD on lipoprotein(a) among South Asian individuals ahajournals.org/doi/10.1161/JA… JAHA OurHealth

Congrats to R. Loos, J. Hirschhorn, & colleagues developing a new polygenic risk score for obesity. Very interesting that it predicts response with weight loss across 2 lifestyle intervention RCTs nature.com/articles/s4159… Nature Medicine My comments in The New York Times

The anti-inflammatory power of semaglutide (Ozempic) seen by its normalization to healthy of a 72 protein signature tied to MASH liver disease nature.com/articles/s4159… Nature Medicine

Probably the most promising use of proteomics in drug development is creating signatures that act as surrogates for hard endpoints in early phase trials. In a MASH trial, semaglutide showed dose-dependent effects on serum proteomic signatures of liver histology mirroring actual

There are much more structural variants within our genomes than previously conceived, >26,000 per person nature.com/articles/s4158… nature.com/articles/s4158…

Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases go.nature.com/3H6pAlr

A study in Nature found that weight loss reduces cell senescence in people with obesity but doesn’t fully reverse all metabolic issues associated with obesity. go.nature.com/4lPewIs

Absolutely fascinating paper! Some of the best examples of learning from evolution comes from non-human GWAS. A missense mutation (discovered previously via a GWAS) in FREP1 encoding a mosquito gut protein provides near complete resistance to malarial parasite infection. The

For specific traits, polygenic risk scores (PRS) can be powerful tools for predicting adverse outcomes. They might offer opportunities to unlock early interventions with potential for massive public health impact. Obesity is one of these traits👇

Our study led by Tiffany Bellomo and with Aniruddh Patel describes the relationship between lipoprotein(a) and incident & progressive extracoronary atherosclerotic vascular disease ahajournals.org/doi/10.1161/CI… Circulation

🚨 Excited to share our new manuscript in @circAHA led by Tiffany Bellomo and team. We evaluated lipoprotein(a) as a prognostic marker for extracoronary atherosclerotic vascular disease progression in UK Biobank. 👉 doi.org/10.1161/CIRCUL… 🧵1/6

Some very interesting reads on genetics & omics from last week🧵

Elevated Lp(a) is linked to both PAD & carotid stenosis! Check out our new paper in @circAHA: doi.org/10.1161/CIRCUL… For 75 nmol/L ↑ in Lp(a): 🔹 PAD risk ↑18% 🔹 Carotid Stenosis risk ↑17% For Lp(a) ≥150 nmol/L with baseline disease: 🔺 MALE risk ↑60% 🔺 Stroke risk ↑40%

Check out Aniruddh Patel's in-depth look at our new paper on lipoprotein(a) as a prognostic marker for extracoronary atherosclerotic vascular disease progression. Lp(a) isn’t just about heart disease, it’s linked to PAD and carotid stenosis too! Mass General Surgery Mass General Vascular

NEW from our group Broad Institute Mass General Heart Patrick Ellinor led by Shino Kany and Sam Freesun Friedman ECG2CAD: An AI model for detection of coronary artery disease using 12-lead ECGs JACC Journals sciencedirect.com/science/articl…