'A #genetic map of the mouse dorsal vagal complex and its role in #obesity' in Nature Metabolism CBMR's Tune H. Pers and Mette Q Ludwig used an unbiased approach to characterize brainstem cell population that anti-obesity drugs likely act to reduce appetite. 🌐cbmr.ku.dk/news/2020/a-ce…

Mapping brainstem cell types relevant to obesity 🌿 nature.com/articles/s4225… Thx to Mette Q Ludwig @metabolcenter for the hard work & thx to Martin G. Myers University of Michigan, Lotte Bjerre Knudsen & collaborators for their inputs, and Novo Nordisk Foundation Lundbeckfonden for financial support.

Danske forskere har dirket hjernens fedmeboks op. Studiet er publiceret i Nature Metabolism og åbner for ny viden om celler der er med til at regulere fedme. Peger på nye former for medicin mod overvægt. lundbeckfonden.com/uddelinger-pri… Tune H. Pers Mette Q Ludwig @metabolcenter Novo Nordisk Foundation

Delighted to share work from my postdoc, co-advised by Neville Sanjana and Tuuli Lappalainen! It began with wanting to identify target genes for GWAS with CRISPR screens and single-cell seq. Brief look below, with shout-outs to my amazing co-authors! Link: biorxiv.org/content/10.110…

The scientists believe the approach will unlock more secrets about the neurological control of appetite and energy balance #dkforsk healthsciences.ku.dk/newsfaculty-ne…

Mapping of cell populations in the brainstem bodes well for future obesity treatment Mette Q Ludwig @DDA_Denmark & NNF Center for Basic Metabolic Research (CBMR) funded phd student. 1.author of international publication in Nature Metabolism Congrats. Tune H. Pers danishdiabetesacademy.dk/news/mapping-c…

Fantastic paper from Iain Clark Cristina Gutiérrez-V Michael Wheeler and Fran Quintana Lab introducing RABID-seq, which virally barcodes connecting cells in the CNS, and investigates the effects of cellular interactions on single-cell gene expression science.sciencemag.org/content/372/65…

#AIM2021 kicks off today! 🎉 Tune in from 16:00-17:30 CET for Pedro Beltrao & Emma Lundberg. Read more about their presentations, and register for free, on our website! 👇 cbmr.ku.dk/artificial-int…

Absolutely foundational work from my pioneering labmate Ken Tao and John Campbell, figuring out the wiring logic of vagus motor neurons: sciencedirect.com/science/articl…

Excited for this 👇💻

Are you interested in #GIP, a gut #hormone with broad effects on #appetite, #satiety, #obesity and #insulin secretion? Don't miss Drs. Makoto FUKUDA BCMHouston and Tune H. Pers University of Copenhagen talk at the upcoming American Diabetes Association - DiabetesPro meeting: adameetingnews.org/live-updates/s…

The brainstem may be important for the effects of GLP-1 and GIP receptor agonists on body weight. How can advancing single-cell techniques be applied to study incretin action in the brainstem?🕵️We wrote a review on this. diabetes.diabetesjournals.org/content/early/… Tune H. Pers Petar NNF Center for Basic Metabolic Research (CBMR)

Preclinical studies of GIP action on aversive pathways lead to the prediction that "combinatorial pharmaceutical targeting of GLP-1R and GIPR will increase efficacy in treating #obesity and #diabetes by reducing nausea and vomiting" diabetes.diabetesjournals.org/content/early/…

Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data. #scRNAseq #CellSubpopulations nature.com/articles/s4158… Nature Biotechnology

More insight into GABAergic LepRbGlp1r neuronal populations and crucial roles in the control of food intake and body weight by #leptin in mice bioRxiv #obesity biorxiv.org/content/10.110…

More data in mice highlighting anti-aversive GIP action via brainstem GIPR circuits-GIPR neurons project locally and selectively inhibit nausea-related GFRAL neurons Cell Reports cell.com/cell-reports/f…

Happy to have contributed to this review with Tune H. Pers, Randy J. Seeley, Ph.D. and Martin G. Myers! 👇

Checking in at Obesity Week #OW2022 in San Diego. Excited to be presenting our work on the Transcriptional states underlying cagrilintide signaling in the dorsal vagal complex on Friday (32AB 1.45 pm PDT). With Tune H. Pers, Martin G. Myers, and Novo Nordisk. NNF Center for Basic Metabolic Research (CBMR)