Their parents bring them to their PCP and are like, “Quinn is 792 months old and still lives in someone’s basement and can’t afford a car...should I be worried?”

1/ Covid (UC San Francisco) Chronicles, Day 282 Holiday greetings – hope you’re getting a little R&R. I’m on clinical svc @ucsfhospitals – welcome break from a Life of Zoom, leavened by a little Netflix. Today, update on Covid in SF/CA, & lessons from first 2 wks of vaccine distribution.

# Thrombocytopenia Don’t worry, we’ve put our best clinical experts to the case. We have a plan. All will be well. With every ounce of conviction we have, we will valiantly and without fail: ⁃CTM

Well that escalated steadily for four years.

I’m thrilled to share a major portion of my PhD work, now out in Nature Medicine, in which we associated rare loss-of-function variants on an exome-wide scale with various clinical phenotypes captured in the EHR to uncover new gene-disease relationships! bit.ly/3pW71

While your office may be frozen at March 2020, hospital IT systems have only made it to 2003

Cellular therapy meets small molecule targeted therapy: CAR-Ts deliver enzymes to convert systemic prodrug in tumor microenvironments. Could be way to rescue good idea drugs that failed due to off-target toxicity. nature.com/articles/s4158…

Excited that the GIANT consortium height GWAS: A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries biorxiv.org/content/10.110… is on biorxiv! Great effort from 100s of investigators and GIANT height working group,

Nice work out of the Viswanathan lab, diving into (among others) the many ways AR expression is driven by rearrangements in mCRPC.

I teamed up with Aaron Newman Lab to answer an important clinical question via #liquidbiopsy: Can peripheral blood features predict severe #immunotherapy toxicity? Very excited to share our results Nature Medicine: nature.com/articles/s4159…

Phenomenal paper just published in Science persuasively demonstrating that EBV causes most if not all multiple sclerosis. Phenomenal epidemiological design and technical achievement. 👏 science.org/doi/10.1126/sc…

On heme consults and struck by how the pathologists remind me of sommeliers. *swills glass* “Normal cellularity” *sniffs* “…trilinneage hematopoiesis” *sips, pauses* “No abnormal lymphoid aggregates…oh look at that megakaryocyte…mild left shift…likely reactive. Very nice”

Today we report in biorxiv programmable RNA sensors that express any protein gated on specific RNAs in a cell. Much like gene sequencing necessitated gene editing tools, we answer “What is the Cas9 of single cells?” 🧵👇🏼w Jonathan Gootenberg & Fei Chen Lab 1/17 biorxiv.org/content/10.110…

The evolutionary velocity paper ended on a cliffhanger: protein language models could predict evolution retrospectively, but could they also run evolution forward to prospectively design new proteins? So, I retrained as a protein biochemist to find out... biorxiv.org/content/10.110…

As #ASCO23 kicks off, don't miss this excellent Oncology Grand Rounds published earlier today in Journal of Clinical Oncology by Drs. Mark Pomerantz, Jeremiah Wala, and Paul Nguyen! "Early Treatment Intensification in Metastatic Hormone-Sensitive Prostate Cancer" ascopubs.org/doi/abs/10.120…

Out nature today! Excited to finally share our work led by Juliann Shih in collab w/ Rameen Beroukhim. Our algorithm “BISCUT” looks at large chromosomal changes and aneuploidy in cancer to detect genes that can account for effects on cellular fitness. nature.com/articles/s4158…

What if small molecules could allow you to alter protein localization at will? What if they could allow you to turn on specific transcription factors? Our new manuscript reveals bifunctional molecules to do just that. 🧵

Exciting news! Our recent collaboration with UK partners identified a key IL7 SNP 🧬 linked to irAEs across diverse cancer cohorts. Sasha Gusev @GrohaStefan Maxine Sun Eddy Saad @[email protected] OncoAlert Nature Medicine nature.com/articles/s4159… nature.com/articles/s4159… We're

If u think u get hard questions as a parent wait till u get "what happens there"