A really interesting paper arguing against our thesis that the temozolomide signature is mediated in part by loss of mismatch repair:
nature.com/articles/s4146…

(I should have posted this earlier but have been avoiding twitter due to its ~recent changes)

An awesome commentary from Howard Fine aacrjournals.org/cancerdiscover…

The Dana-Farber Pediatric Low-Grade Glioma program is hosting an open house at DFCI on November 13th. We would love to meet anyone who is interested in learning more about #PLGG #PLGA , our research and our program Dana-Farber Dana-Farber/Boston Children's

Out nature today! Excited to finally share our work led by Juliann Shih in collab w/ Rameen Beroukhim. Our algorithm “BISCUT” looks at large chromosomal changes and aneuploidy in cancer to detect genes that can account for effects on cellular fitness.
nature.com/articles/s4158…

(1/7) The approach researchers use for #CRISPR guide design can accidentally perpetuate ancestry-related false negatives in cancer target discovery – that’s the key point of new biorxiv report from us and Rameen Beroukhim broad.io/ancestryCRISPR Broad Institute Dana-Farber

A new analysis finds that failing to account for ancestry slightly skewed a massive sweep for cancer genes, causing it to miss genes important as drug targets in those of recent African descent. scim.ag/EE

I hadn't expected this one

Detection and localization of early- and late-stage cancers using platelet RNA pubmed.ncbi.nlm.nih.gov/36055228/

Nice paper by Sohrab Shah and colleagues on biomarkers of immunotherapy response

Multimodal integration of radiology, pathology and genomics for prediction of response to PD-(L)1 blockade in patie… pubmed.ncbi.nlm.nih.gov/36038778/

Nice review on ecDNA by Anton Henssen and Roel Verhaak labs …-nature-com.ezp-prod1.hul.harvard.edu/articles/s4157…

Thanks to Dana-Farber and Rob Levy for sharing our work in understanding how #dipg and other #PedBrainTumors grow.

We are indebted to the children and families who contribute so much to help other kids.

Keith Ligon Rameen Beroukhim
Nature Cancer

blog.dana-farber.org/insight/2022/0…

Excited to share our work on #pHGGs and #DMGs . This wouldn't have been possible without the families who donated samples so that we can learn. Well done to Frank for leading this collaboration between the Bando, Beroukhim and Ligon labs and many others.

nature.com/articles/s4301…

Out today (Happy4th🇺🇸!) Bando/Ligon/Beroukhim team manuscript led by Frank Dubois w/AMAZING crunch of WGS on 179 pHGG defines new SV drivers & power of SV sigs as biomarkers. Thx2 Pediatric Brain Tumor Foundation National Cancer Institute and 🙏 #glioma patients and families
rdcu.be/cQXC8
nature.com/articles/s4301…