We’re excited to share our work developing a new gene editing approach that we’re calling #clickediting 🖱️✴️🧬. Click editors (CEs) utilize DNA-dependent polymerases to write bespoke edits into the genome. biorxiv.org/content/10.110… CGM at MGH MassGeneral News Mass General Research Institute Harvard Medical School

progress: my subconscious has graduated from a decades-long recurrent dream where I forget all semester to attend the college class I signed up for to a dream where I have the sudden realization that I somehow forgot to finish the faculty job talk I started giving 🙃

To our friends and colleagues abroad: we’re experiencing a terror attack the size of 9/11 with war crimes and atrocities that remind us of the holocaust. ISIS-type barbaric mass murdering of civilians, slaughtering of babies, torturing and raping of abductees.

Of all the stories I've read or heard the past few days, Amir Tibon אמיר תיבון's is the most remarkable—capturing the horror, the failures, the heroics, the hope, and the despair of this moment in Israel. theatlantic.com/ideas/archive/…

Friends and academic colleagues from across the world, thank you for your unequivocal support The facts: On Saturday, Hamas slaughtered >900 people and kidnapped >100, inc. children, elderly, and entire families. Babies were shot at gunpoint. Only because they were Jewish >>>

Have you ever wondered, "Despite a sea of eQTLs in the GTEx database, why I couldn't find an eQTL for my favourite gene in the GWAS locus?" This paper provides a thoughtful explanation. The one-word answer is "natural selection". The long answer is below. Genetic variants

Check out our latest work led by Surag Nair & Mo Ameen using neural nets to dissect the interplay of TF stoichiometry, motif affinity & syntax in fibroblast reprogramming to iPSCs. Several fascinating insights from the models. biorxiv.org/content/10.110… Tweetorial coming soon 1/

Finally won a whiskey lottery! Looking forward to trying this as soon as I finish this pile of email…

Registration for the 7th Annual Mutational Scanning Symposium is now open! This year's meeting will be held from May 22nd-24th at the Broad Institute in Cambridge, MA, USA, and headlined by keynotes from Heidi Rehm and Vijay Sankaran 📝broadinstitute.swoogo.com/mss-2024

I spent countless hours of my life in this building trying to get financial aid (Schmitz Hall, UW)

People need not shy away from studying difficult questions. And the broad acceptance of pre-prints is also an opportunity to have work evaluated and critiqued by the community when the stakes are still low. /fin

and we’re through! #ars

Our paper on functional discovery of protein degradation and stabilization effectors with proteome-scale induced proximity screens is out in its final version! 1/ nature.com/articles/s4158… rdcu.be/dBUju

At long last, the in4mer paper is published! In4mer is our CRISPR/Cas12a platform, developed in collaboration with John Doench, where we show that expressing 4mer arrays of Cas12a guides turns out to be a highly efficient way to knock out genes singly or in combination.

ONLY 12 DAYS AWAY: The 2024 Mutational Scanning Symposium, hosted by Broad Institute , opens on May 22. If you have not already registered, please do so ASAP. Atlas of Variant Effects Alliance Harvard University Massachusetts Institute of Technology (MIT) broadinstitute.swoogo.com/mss-2024/51014…