CGM at MGH & PNGU scientists including Karestan Koenen, Jordan Smoller, karmel choi and colleagues identified 95 genetic variants associated with PTSD, improving risk prediction and potential treatments Harvard Medical School more here: nature.com/articles/s4158…

Today we announce the submission to #ClinVar of >32,000 variants evaluated for the return of hereditary disease risk in the AllofUsResearch cohort. Its wonderful to return value to those who contribute their data to biomedical research! More details here: allofus.nih.gov/news-events/an…

CGM at MGH faculty Dr. Stephen Haggarty, trainee Zach Rosenthal & colleagues identify BET bromodomain proteins as novel targets for the treatment of progranulin-deficient frontotemporal dementia. More here: nature.com/articles/s4159…

Researchers from CGM at MGH and colleagues investigate how genetic diversity in the immune system can affect the likelihood of developing lung cancer, in a @sciencemagazine study. doi.org/10.1126/scienc…

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On 5/21 at 6pm ET, join a hybrid discussion of the past & future of psychiatric diagnosis & care, featuring
NAMI Massachusetts/NAMI community peers & family members, and scientists from Broad Institute's Stanley Center for Psychiatric Research. More at broadinstitute.swoogo.com/mentalhealthta…

New study in JACC Journals shows that clonal hematopoiesis may stratify risk of CV death among individuals with asymptomatic carotid artery stenosis.
jacc.org/doi/abs/10.101…
Delighted to work with Tiffany Bellomo Mass General Vascular on the accompanying editorial
jacc.org/doi/10.1016/j.…

Managing differential performance of polygenic risk scores across grou... sciencedirect.com/science/articl…

CGM at MGH associate member and MGH Urology faculty Keyan Salari & colleagues find integration of family history + germline genetics refines risk stratification to help individualize prostate cancer care. More here: auajournals.org/doi/10.1097/JU…

CGM at MGH faculty Pradeep Natarajan, Alicia Martin and colleagues outline a new statistical framework combining genetic scores, enhancing disease risk prediction accuracy. More here: cell.com/cell-genomics/… Yunfeng Ruan🌻 #StandWithUkraine🌻 Ying Wang

mtDNA heteroplasmy dynamics are so complex, even paradoxical. To understand why, we combined precise mtDNA editing w/a new method SCI-LITE. In dividing cells, selection (not drift) acts on cell (not intracellular) fitness to shape population heteroplasmy. rdcu.be/dFDCY

Patricia Musolino, MD, PhD, is studying a rare cerebrovascular disorder to develop approaches that may bring promising gene therapy technologies into the clinic. spklr.io/6018opT6

We have an exciting lineup of speakers for this year's 4th Annual Conference on Precision Psychiatry!

Students, fellows, interns, and trainees can register for free!

Register today at mghcme.org/precision2024

Questions can be directed to [email protected]

Check out a new article in preprint, from Broad Clinical Labs and collaborators at the Broad's Stanley Center, where we describe the Blended Genome Exome (BGE) technique as a cost effective alternative to deep whole genome sequencing and a less-biased data type for imputation and…

CGM at MGH Investigators Jong-Min Lee, Jim Gusella, Marcy MacDonald, Vanessa Wheeler & colleagues found that genetic variant rs3512 changes a target recognition sequence of miR-124-3p, modifying Huntington’s disease onset by altering FAN1 levels. Read more: pubmed.ncbi.nlm.nih.gov/38607933/

Congratulations to CGM at MGH and MassGeneral Medicine faculty Raghu Chivukula, MD PhD 🫁 who is a recipient of both an award from the Smith Family Award Program for Excellence in Biomedical Research and an MGH Department of Medicine Transformative Scholar Award!

Congratulations to CGM at MGH and MGH Neurology faculty member Dr. Florian Eichler who was recently named the new Katherine B. Sims, MD, Endowed Chair in Neurogenetics!

Different causes of delayed puberty have different genetic origins. CGM at MGH Harvard Medical School Boston Children's Kallmann syndrome & CHH Read more from @margaret_lippincott and colleagues: academic.oup.com/jcem/advance-a…