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When guidelines do not match the evidence--the story of beta-blockers after MI sensible-med.com/p/when-guideli… If the pill itself comes with an expiration date, why shouldn't the evidence? Sensible Medicine Andrew Foy

Restoring Gold Standard Science is Far More than Stopping Fraud , by John Mandrola, MD open.substack.com/pub/johnmandro…

I just recorded an excellent podcast with Andrew Foy Mohammed Ruzieh, MD on the below HF trials. Coming Friday on Cardiology Trials I learn so much from these two. Teaser: there is a bunch of nuance in our GDMT evidence

That was bike racing! A spectacle.

I loved the stage today. Nico makes a gap on a corner in a criterium. 5 meters is all. Then he holds it for 20 min. I’ve been in “group 2” more times than I’d like to admit. Bike racing is a beautiful sport. It’s no small thing to make separation on a flat road. Then hold it.

New from John Mandrola, MD No, the KETO-CTA Study Did Not Upend Causal Evidence on Atherosclerotic Cardiovascular Disease medscape.com/viewarticle/no…

No, the KETO-CTA Study Did Not Upend Causal Evidence on Atherosclerotic Cardiovascular Disease medscape.com/viewarticle/no… via John Mandrola, MD

On KETO-CTA by ⁦John Mandrola, MD⁩ “…on the authors’ messaging. It’s been egregious and antiscientific... I don’t know what the solution is for this behavior, but I oppose it in the strongest terms.” medscape.com/viewarticle/no…

A wonderful essay by one of our students. sensible-med.com/p/the-patch-of…

Agree with this take by John Mandrola, MD. The many limitations of the study design are one thing, but the real scandal is the attempt to spin the results both in the writing of the paper & on social media. Unacceptable, reckless, unserious behavior that victimizes the most vulnerable

Perhaps “academics” is a mindset not dependent on what the sign on the outside of a building says 👇🏻

Look for a critical appraisal of this study tomorrow on Sensible Medicine I will look beyond the headlines from the 85 news sites (thus far) covering it. #ASCO25

Who is filling in Vinay Prasad MD MPH shoes for critical appraisal & common sense interpretation of new onc studies from ASCO? Our journals, funders, experts, societies fail us miserably Aaron Goodman - “Papa Heme” Timothée Olivier, MD Bishal Gyawali, MD, PhD, FASCO

Stay tuned to Sensible Medicine tomorrow