Just out! Should you be worried about Bird Flu?
I offer 7 thoughts on H5N1, and the implications of it being detected in the milk supply
drvinayprasad.com/p/should-you-b…

If you are interested in working with us VKPrasadLab

You can contact us here
vkprasadlab.com/join

Finally read more about this issue on Sensible Medicine
open.substack.com/pub/sensibleme…

I want to live in a world where medical students and residents are more excited about Sensible Medicine than Anki or UWorld.

Happy to be a new paid subscriber.

Our latest paper led by med student Josh Elbaz👇

68% of cancer drug approvals don't have evidence they increase survival!

Let me explain some key findings about the FDA
#1. Both regular and accelerated approvals are based on surrogates...
dx.doi.org/10.1002/cam4.7…

👇👇👇👇
pubmed.ncbi.nlm.nih.gov/36608747/
city-journal.org/article/bidens…

Presented this to our HM group today.
Lots of good writing on this to date. I appreciate the thoughts of Sensible Medicine John Mandrola, MD and Vinay Prasad MD MPH on the matter.

If you haven't read REDUCE-AMI yet, go ahead and do so. Likely a big step for de-prescribers everywhere.

Further thoughts on Patient advocates, payments from pharma, and why MRD negativity is about forcing CMS and insurers to pay and not FDA approval/ access

A must listen!

This is the money statement: “Even though I am a physician and trained in the scientific method, I am pretty bad at assessing risks.” #virtuesignalling
#covid ⁦Sensible Medicine⁩ sensible-med.com/p/is-it-ok-for…

I really like this column. Not only because I agree with it, but also because the author makes a strong argument

We are recruiting!
Looking for policy analysts UCSF Epidemiology & Biostatistics VKPrasadLab

Projects on cancer drug policy-- sp. low value services & public health policy-- sp. not evidence based

Opportunity 2 publish!
Great for people going into medicine or policy
sjobs.brassring.com/TGnewUI/Search…

Vinay Prasad MD MPH working on the weekend.

On Sensible Medicine he exposes lax regulation at FDA re multiple myeloma Rx. sensible-med.com/p/unproven-hea…

On his substack he writes about the double standard re reporting efficacy vs harm in RSV vaccine trials open.substack.com/pub/vinayprasa…

👆👆

'It struck me that this was a double standard. If a non-significant difference can be called “modest efficacy,” a 1% numerical increase in preterm birth (also not significant) should be a modest harm.'
drvinayprasad.com/p/open-concern…

Dr. Vinay Prasad MD MPH makes important points about survival endpoint in U.S. FDA FDA Oncology drug approvals👇(see video as well)
youtu.be/-42d0z9faao?si…

My comments at Friday's FDA drug advisory meeting

drvinayprasad.com/p/my-comments-…

'Doctors are already allowed to prescribe these drugs (off-label)... In fact, the FDA’s accelerated approval won’t grant access... but rather, I fear, is a grand strategy to force insurers & Medicare to pay for... uncertain drugs.'
Now on Sensible Medicine
open.substack.com/pub/sensibleme…

My comments at the FDA ODAC on MRD as an accelerated approval endpoint in Myeloma

Safety is the big reason this is a bad decision

Vinay — I agree w all of this and would add that there’s no better measure for body fat than putting on a Euro-sized bike jersey

Just posted the 'Improving Your Critical Appraisal Skills 2' on Cohorts on Sensible Medicine this week. I think this article might have to be included in the articles to read section.

Mortality Among Users of Anabolic Steroids jamanetwork.com/journals/jama/…

Just learned more about RCTs in this 1 Sensible Medicine article than in an entire HSPH stats/epi course I took during a summer in residency.

Everything in this thread is incorrect. Literally every recommendation. Here's a thread why. 1/7