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Grateful to work with Eric Smith & outstanding collaborators incl Neal Lakdawala Daniel Jacoby Elizabeth McNally Lisa Wilsbacher Gregory Aubert MD, PhD. Great to see recurring themes in others just out Nicolas Piriou et al European Society of Cardiology Journals, Poller et al JAHA, Gandjbakhch et al Circulation: Genomic and Precision Medicine

EXPLORER-HCM CMR substudy finds that mavacamten favorably impacts cardiac structure in obstructive HCM. Read more: ow.ly/Iobx50DxLH0 #AHAJournals @S2beri

⚡Out today from Chris Haggerty + team: Clinical Findings and Diagnostic Yield of Arrhythmogenic Cardiomyopathy through Genomic Screening of Pathogenic Desmosome Gene Variants ahajournals.org/doi/abs/10.116… AHA Science #ahajournals #cardiogen 📽️Jeanette Erdmann Anwar Chahal MD PhD MRCP

Our work in childhood-onset HCM now published in #EHJ European Society of Cardiology Journals Take Home Points: 1) 3 peaks of HCM onset, peak in teens driven by Sarcomeric HCM 2) ~15% of HCM is diagnosed in childhood, carrying ~2%/yr event rate 3)⬆️risk of VT & VAD/Transplant compared to adult-onset

Our paper on “The genetic architecture of Plakophilin 2 cardiomyopathy” is now online at Genetics in Medicine. Please check it out (and/or read the thread below) at rdcu.be/cmqCE ! 1/n

Super excited to release genebass.org, a web application for browsing association results for 3,700 phenotypes across 281,850 individuals from the UK Biobank. The site features plots, tables, and controls for exploring billions of associations.

Excited to share our work on iPSC-derived 2D cardiac muscle bundles. Accessible and reproducible contractile assessment, insights on cardiac development, disease modeling. Read Nature Communications rdcu.be/cz3pD Baker Lab Dr. Lori L. Isom yuweiwu_imb U-M Health Frankel CVC

In this randomized phase 2 trial, Valsartan improved cardiac structure and function in patients with early-stage sarcomeric HCM compared to placebo. Nature Medicine Giuseppe Limongelli Federica Ilardi francesca graziani_FG iacopo olivotto Sara Moscatelli Francesco Perone nature.com/articles/s4159…

Excited to share some new work from us today on ultra-rapid genome sequencing for the diagnosis of critically ill children and adults. In critical care settings, genetic diagnosis can shorten stays, direct precision therapy, save money, and help with family planning. 1/

Outstanding Journal of Clinical Investigation review about novel myosin-based interventions! Jil C. Tardiff, M.D.,Ph.D. @sday_hcm JCI - Myosin modulators: emerging approaches for the treatment of cardiomyopathies and heart failure jci.org/articles/view/…

Like everything else she writes, a must read in JACC Journals #JACCHF from Alin Gragossian, DO, MPH 💙💚 Critical Importance of Genetic Screening in Family Members #cvGenetics jacc.org/doi/epdf/10.10…

#OriginalResearch In mice models, dysfunction adhesion was demonstrated to play a key role in the pathophysiology of arrhythmogenic cardiomyopathy #AHAJournals ahajrnls.org/3Nyu57q

Proud to see this world wide effort for #DSP finally out! Kudos to my DSP-erados partner Richard Carrick for bringing this paper home and thanks to the many collaborators Alex Protonotarios Hugh Calkins Mikael Laredo Adam Helms Victoria Parikh, MD J.Peter van Tintelen Anneline te Riele Julia CadrinTourigny