Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner dlvr.it/Sjk438

A study led by Dr. Rafael Kramann (@Rafael Kramann, MD PhD) and team investigated a platelet-derived #chemokine mediates SPP1+ #macrophage activation and organ fibrosis. Read more about how SPP1+ macrophages expand in human heart failure and chronic #KidneyDisease: 📌 bit.ly/3SwBSFc

New research demystifies the immune landscape that drives #glomerulonephritis—and shows that targeting a #Tcell-monocyte-derived cell axis dampens inflammation in mice with this chronic kidney condition. #Nephrology @burkhard_becher CKLab scim.ag/1ZH

Right now at #ESM2023: Konrad Hoeft shows that targeting the #Adamt12 pathway in #pericytes prevents the heart and kidney against fibroblast differentiation and thus fibrosis. Intriguing findings! #SpatialTranscriptomics European Society for Microcirculation (ESM)

After many years of development and refinement, here is our preprint showing a new toolbox for high-throughput scMosaic genetics in mice 👉"iFlpMosaics". Led by Irene IreneaBio with the great contribution of several scientists and technicians in our lab. biorxiv.org/content/10.110…

This week, the world broke the daily temperature record. This is yet another demonstration that climate change is out of control and one reason more for increased #ClimateAction ambition and justice.

For more than a decade, the EU has been sending billions of tax payers euros for what are essentially anti-migration projects in Africa. For the past year, I took a deep dive into how that looks like in Senegal for In These Times inthesetimes.com/article/europe…

New #genetic analyses in mice and human cells uncover how chronic kidney disease may contribute to heart disease by altering cardiac cells. scim.ag/4WJ

Do you have #singlecell or #pathomics disease atlas and want to perform sample level analysis? Check out how PILOT finds and interprets sample level trajectories and clusters by Mehdijoodaki & @MinaShaiga with @LaBOORatory Rafael Kramann, MD PhD Christoph Kuppe embopress.org/doi/full/10.10…

🎉 Happy to share our first 📜 2024!🔬 Our review article in Genome Medicine on the innovative use of spatial multi-omics. Discover how these technologies are unlocking new understandings of cardiovascular disease. 🚀rdcu.be/dwnVi Uniklinik RWTH AC Springer Nature RWTH Aachen

The research of Andrei Popoviciu and colleagues indicates the entanglement of European funds in repressive and anti-democratic projects in Senegal. The EU is committed to respect human rights in intercontinental cooperation. European Commission

academics-Nachwuchspreis 2023: Carolin V. Schneider, MD, die #Informatik und #Medizin zur Behandlung von Stoffwechselerkrankungen verbindet, im Porträt. academics.com Uniklinik RWTH AC RWTH Aachen #GalaDerDeutschenWissenschaft youtu.be/eAcEEyPt_UA

Congratulations Kai Markus Schneider! 🙌🏼🍾🍾

Now online! Innate immune memory after brain injury drives inflammatory cardiac dysfunction dlvr.it/T9wvwD

Fibrosis Uncovered: ADAMTS12 cuts to the core of extracellular matrix drama: jci.org/articles/view/… Bernhard Dumoulin & Katalin Susztak Penn Medicine comment on Hoeft et al. (jci.org/articles/view/…)