Tremendously proud to share my fellowship work, online today in Nature Medicine. We tried to understand why CAR T therapy for AML doesn't work as well as we hoped it would, and how we can solve that. 👇🧵1/10 Penn Medicine CHOP Research Saar Gill nature.com/articles/s4159…

Thanks to all the support from UMass Chan Medical School UMass Chan Department of Neurobiology. It is a honor to be part of this community.

nature.com/articles/s4159… Itching can be annoying but could it also be beneficial? Maybe it’s your body 🚨 you of a secret invasion… Our freshly baked manuscript is trying to answer these and other neuron, 🪱 and macrophage-related questions. (1/n)🧵 👇🏼

New protocols from Jessica Kahng and Andre Xavier for quantifying synapse engulfment by OPCs, based on foundational work from ⁦SchaferLabUMassChan⁩ ⁦beth stevens⁩ ⁦Won-Suk Chung⁩ and others (1/4) nature.com/articles/s4159…

!!!!!!!!!!!!!! 🔥🔥🔥🔥💯💯💯💯💯🔥🔥🔥🥂🥂🥂🥂🤪👍👍👍

📢Great speaker line-up: Belinda Pletzer @PLUS_1622, Roxana Zeraati & Matthias Philipp Baumann, Read Montague Fralin Biomedical Research Institute, Romy Lorenz Max Planck Institute for Biological Cybernetics, Lisa Genzel Radboud University, Iain Couzin MPI-AB is on Bluesky @mpi-animalbehav.bsky.social, Emilie Mace Universitätsmedizin Göttingen (UMG) & Chris Bennett Penn 📅Program tinyurl.com/4pvv48yp

So delighted that one of my very favorite scientists and people Dr Allen is a Pioneer Awardee (you heard it here first!) woooohooo! Salk Institute

Congrats to Children's Hospital's Dr. Evan Weber, recipient of the @NIHDirector's New Innovator Award! Dr. Weber will pursue a novel approach to reprogram T cells with enhanced tumor killing function, paving the way for more efficacious #cancer therapeutics. Cancer Center @ CHOP

One of the best ways to spend a sunny day in Philly is with these brilliant, creative,  and fun people! So honored to work with this awesome team! Happy #newpi Morris-Blanco Lab #strokeresearch

🚨Postdoc positions available🚨 If you have expertise in T cell biology (primarily TCR specificity/function) and/or in artificial intelligence, and if you would like to apply your knowledge to cool questions in #neuroimmunology, please email me for inquiry.

Excited to share our new paper where we explore why dCas9-KRAB protein levels drop so drastically after neuronal differentiation in WTC11 and KOL2.1J iPSC lines. biorxiv.org/content/10.110…

looking forward to tomorrow!!

New paper ALERT!! Mara Cowen discovered and defined how conserved autism-associated genes modify a 'social' behavior in C. elegans!! So proud of her work in the lab! nature.com/articles/s4146…

Interested in studying type I interferonopathy? Here is a primer on existing tools from the self proclaimed "AGS supergroup". doi.org/10.1111/imr.13…

Thrilled to share new work from our lab led by ⁦Mitchell (Min Woo) Kim⁩! The results provide new insight to immune privilege and hopefully diagnostic/therapeutic tools || Endogenous self-peptides guard immune privilege of the central nervous system | Nature nature.com/articles/s4158…

We are excited that our work describing microglia cannibalism is now officially in press! journals.plos.org/plosbiology/ar… Stay tuned because we are on to the genetic mechanisms! 😀

Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells dlvr.it/TPDLwc #genetherapy #celltherapy

CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies dlvr.it/TPDM43 #genetherapy #celltherapy

Microglia replacement via vascular delivery and no toxic preconditioning? Now THAT is something I can get excited about. In our new paper we find that microglia replacement can now be achieved by peripheral delivery w/ no irradiation or chemo required. 👉 doi.org/10.1016/j.ymth…

Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells cell.com/molecular-ther… cell.com/molecular-ther… Molecular Therapy Family of Journals Chris Bennett Sonia Lombroso Blurton-Jones Lab Jean Paul Chadarevian UC Irvine Penn